Acic 5% Cream

Acyclovir 5% Topical
50mg/g
HEXAL AG
Pack size 5g Tube
Dispensing mode POM
Source GERMANY
AgentALPHAMED CO. (AUH) LTD.
Retail Price 55.50 AE

Indications

Acic 5% Cream is used for: Herpes virus infections of skin

Adult Dose

As 5% oint/cream: Apply to the affected skin 5-6 times/day for 5-10 days.

Child Dose

Renal Dose

Administration

Contra Indications

Hypersensitivity.

Precautions

Renal impairment. Pregnancy, lactation. Neurological abnormalities with significant hypoxia, serious hepatic or electrolyte abnormalities. Maintain adequate hydration. Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application.

Pregnancy-Lactation

Pregnancy category: B Lactation: Excretion in milk unknown; systemic exposure is minimal after topical application

Interactions

Probenecid, cimetidine and mycophenolate mofetil may increase the plasma concentration of aciclovir. Increased nephrotoxic effects w/ drugs that affect renal physiology (e.g. ciclosporin, tacrolimus).

Adverse Effects

Side effects of Acyclovir 5% Topical : >10% Burning/stinging (30%) 1-10% Pruritus (4%) <1% Dry lips (<1%), Rash (0.3%) Frequency Not Defined Angioedema, Vulvitis

Mechanism of Action

Activity against HSV types I and II and varicella-zoster virus is due to intracellular conversion of aciclovir to the monophosphate by viral thymidine kinase with subsequent conversion to the diphosphate and active triphosphate by cellular enzymes. This active form inhibits viral DNA synthesis and replication by interfering with viral DNA polymerase enzyme and being incorporated into viral DNA.

Note

Acic 5% 50mg/g Cream manufactured by HEXAL AG. Its generic name is Acyclovir 5% Topical. Acic 5% is avaible in United Arab Emirates. Farmaco UAE drug index information on Acic 5% Cream is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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