Acuitel Tablets
Quinapril
5mg
PARKE DAVIS (GODECKE AG)
| Pack size | 30's (10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | NEW MEDICAL CENTRE |
| Retail Price | 34.00 AED |
Available as:
Indications
Acuitel Tablets is used for:
Hypertension, Congestive Heart Failure
Adult Dose
Hypertension
Initial: 10-20 mg PO qDay; may administer 5 mg in patients receiving diuretic therapy if the diuretic is continued
Maintenance: 20-80 mg PO qDay or divided q12hr
Congestive Heart Failure
Initial: 5 mg PO q12hr
Maintenance: 20-40 mg PO qDay or divided q12hr
Elderly: 2.5-5 mg/day initially; increase dose by increments of 2.5-5 mg at 1-2 week intervals; adjust for renal impairment
Child Dose
Renal Dose
Renal impairment with hypertension
CrCl >60 mL/min: 10 mg/day
CrCl 30-60 mL/min: 5 mg/day
CrCl 10-30 mL/min: 2.5 mg/day
CrCl <10 mL/min: Insufficient data
Renal impairment with CHF
CrCl >30 mL/min: 5 mg/day
CrCl 10-30 mL/min: 2.5 mg/day
CrCl <10 mL/min: Insufficient data
Administration
Contra Indications
History of angioedema related to previous ACE inhibitor treatment, hereditary or idiopathic angioedema. Concomitant use w/ aliskiren in patients w/ diabetes and renal impairment. Pregnancy.
Precautions
Patients w/ diarrhoea, severe volume and/or salt depletion due to prolonged use of diuretics and unilateral or bilateral renal artery stenosis. Patients on dietary salt restriction and dialysis. Severe CHF. Increased risk of angioedema in black patients. Renal and hepatic impairment. Lactation. Monitoring Parameters Monitor BP prior and throughout therapy. Periodically monitor serum creatinine, K levels and CBC.
Pregnancy-Lactation
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimester)
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: excreted in breast milk; use caution
Interactions
Additive hyperkalaemic effects w/ K-sparing diuretics, K supplements, other drugs that can cause hyperkalaemia. Increased lithium concentrations and toxicity. May decrease absorption of tetracyclines. May increase nitritoid reactions of gold Na thiomalate.
Potentially Fatal: Increased risk of hypotension, hyperkalaemia and nephrotoxicity w/ concomitant aliskiren in renally impaired and diabetic patients.
Adverse Effects
Side effects of Quinapril :
1-10%
Dizziness (7.7%), Coughing (4.3%), Fatigue (2.6%), Nausea and/or vomiting (2.4%), Hypotension (2.9%), Dyspnea (1.9%), Diarrhea (1.7%), Headache (1.7%), Myalgia (1.5%), Rash (1.4%), Back pain (1.2%)
<1%
Angioedema
General: Back pain, malaise, viral infections, anaphylactoid reaction
Cardiovascular: Palpitation, vasodilation, tachycardia, heart failure, hyperkalemia, myocardial infarction, cerebrovascular accident, hypertensive crisis, angina pectoris, orthostatic hypotension, cardiac rhythm disturbances, cardiogenic shock
Hematology: Hemolytic anemia
Gastrointestinal: Flatulence, dry mouth or throat, constipation, gastrointestinal hemorrhage, pancreatitis, abnormal liver function tests, dyspepsia
Metabolism and nutrition disorders: Hyponatremia
Nervous/psychiatric: Somnolence, vertigo, syncope, nervousness, depression, insomnia, paresthesia
Integumentary: Alopecia, increased sweating, pemphigus, pruritus, exfoliative dermatitis, photosensitivity reaction, dermatopolymyositis
Urogenital: Urinary tract infection, impotence, acute renal failure, worsening renal failure
Respiratory: Eosinophilic pneumonitis
Other: Amblyopia, edema, arthralgia, pharyngitis, agranulocytosis, hepatitis, thrombocytopenia
Mechanism of Action
Angiotensin converting enzyme (ACE) inhibitors dilate arteries and veins by competively inhibiting the conversion of angiotensin I to angiotensin II (a potent endogenous vasoconstrictor) and by inhibiting bradykinin metabolism; these actions result in preload and afterload reductions on the heart
ACE inhibitors also promote sodium and water excretion by inhibiting angiotensin-II induced aldosterone secretion; elevation in potassium may also be observed
ACE inhibitors also elicit renoprotective effects through vasodilation of renal arterioles
ACE inhibitors reduce cardiac and vascular remodeling associated with chronic hypertension, heart failure, and myocardial infarction
Note
Acuitel 5mg Tablets manufactured by PARKE DAVIS (GODECKE AG). Its generic name is Quinapril. Acuitel is availble in United Arab Emirates.
Farmaco UAE drug index information on Acuitel Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.