Albenda Tablets

Albendazole
200mg
Julphar (Gulf Pharmaceutical Industries)
Pack size 2's Blister
Dispensing mode POM
Source UAE
AgentJULPHAR
Retail Price 6.00 AED

Available as:

20mg/ml - Suspension

Indications

Albenda Tablets is used for: Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis

Adult Dose

Oral Ancylostoma, Ascariasis, Hookworm, Trichostrongylus, Enterobius (Pinworm) 400 mg PO once as a single dose Tapeworm infections Adult: 400 mg daily on an empty stomach for 3 consecutive days. Max: 400 mg daily; 1200 mg for 3 days. If patient is not cured after 3 weeks, a second course of treatment is needed. In cases of Hymenolepis nana infestations, retreatment in 10-21 days is recommended. Strogyloidiasis or taeniasis - 400 mg once daily for three consecutive days. Giardiasis - 400 mg once daily for five days. Hydatid disease (Echinococcosis) Adult: <60 kg: 15 mg/kg daily in 2 divided doses. Max: 800 mg/day. >60 kg: 400 mg bid. Admin dose for three 28-day cycles w/ a 14-day drug-free interval in between each cycle. Neurocysticercosis Adult: <60 kg: 15 mg/kg daily in 2 divided doses (max: 800 mg/day) for 8-30 days. >60 kg: 400 mg bid for 8-30 days. Larva Migrans, Cutaneous & Trichuriasis 400 mg PO qDay x 3 days Larva Migrans, Visceral 400 mg PO BID x 5 days Fluke (Clonorchis Sinensis) 10 mg/kg PO qDay x7 days Gnathostomiasis, Microsporidiosis 400 mg BID x 21 days

Child Dose

Child: Usually PO 15 mg/kg/day (max 800 mg/day) q12h Oral Ascariasis, Enterobiasis, Trichuriasis, Hookworm infections Child: 1-2 years 200 mg as a single dose. OR 5 ml suspension 2 years 400 mg PO once as a single dose OR 10 ml suspension Max: 200 mg. Tapeworm infections Child: >2 years: 400 mg daily on an empty stomach for 3 consecutive days. Max: 400 mg daily; 1200 mg for 3 days. If patient is not cured after 3 weeks, a second course of treatment is needed. In cases of Hymenolepis nana infestations, retreatment in 10-21 days is recommended.

Renal Dose

Administration

Should be taken with food.

Contra Indications

Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.

Precautions

Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease. Lactation: unknown, use caution.

Pregnancy-Lactation

Pregnancy Category: C Lactation: unknown, use caution

Interactions

Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.

Adverse Effects

Side effects of Albendazole : >10% Headache, Neurocysticercosis (11%), Hydatid disease (1.3%), Abnormal LFT, Hydatid disease (15.6%), Neurocysticercosis (<1%) 1-10% Abdominal pain, Hydatid disease (6%), Nausea/vomiting, Hydatid disease (3.7%), Neurocysticercosis (6.2%), Dizziness/vertigo, Hydatid disease (1.2%), Neurocysticercosis (<1%), Increased intracranial pressure, Neurocysticercosis (1%), Meningeal signs, Neurocysticercosis (1%), Alopecia (reversible), Hydatid disease (1.6%), Neurocysticercosis (<1%), Fever, Hydatid disease (1%) <1% (selected) Rash, Urticaria, Agranulocytosis, Aplastic anemia, Bone marrow suppression, Granulocytopenia, Pancytopenia, Thrombocytopenia, Hepatitis, Acute liver failure, Acute renal failure Potentially Fatal: Bone marrow depression.

Mechanism of Action

Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.

Note

Albenda 200mg Tablets manufactured by Julphar (Gulf Pharmaceutical Industries). Its generic name is Albendazole. Albenda is availble in United Arab Emirates. Farmaco UAE drug index information on Albenda Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Albendazole :

Suspension
Zentel 100mg/5ml
SMITH KLINE & FRENCH LABS. SA
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Zentel 200mg
Glaxo Wellcome Production
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Zentel 400mg
GLAXOSMITHKLINE SOUTH AFRICA (PTY) LTD
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Zentilife 200mg
Lifepharma FZE
Suspension
Albenda 400mg/20ml 20mg/ml
Julphar (Gulf Pharmaceutical Industries)