Alghaphan Injection

Dextropropoxyphene HCl
75mg
BOEHRINGER MANNHEIM GmbH
Pack size 2ml Ampoule x 10
Dispensing mode SCD
Source GERMANY
AgentIBN KHALDOON DRUG STORE
Retail Price 23.50 AED

Indications

Alghaphan Injection is used for: For the relief of mild to moderate pain

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Dextropropoxyphene HCl :

Mechanism of Action

Propoxyphene acts as a weak agonist at op1, op2, and op3 opiate receptors within the central nervous system (cns). Propoxyphene primarily affects op3 receptors, which are coupled with g-protein receptors and function as modulators, both positive and negative, of synaptic transmission via g-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of gtp for gdp on the g-protein complex. As the effector system is adenylate cyclase and camp located at the inner surface of the plasma membrane, opioids decrease intracellular camp by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance p, gaba, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close n-type voltage-operated calcium channels (op2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (op3 and op1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability

Note

Alghaphan 75mg Injection manufactured by BOEHRINGER MANNHEIM GmbH. Its generic name is Dextropropoxyphene HCl. Alghaphan is availble in United Arab Emirates. Farmaco UAE drug index information on Alghaphan Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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