Artamin Capsules (Hard Gelatin)
Penicillamine-d
250mg
BIOCHEMIE GmbH
| Pack size | 50's (10's Blister x 5) |
|---|---|
| Dispensing mode | POM |
| Source | AUSTRIA |
| Agent | ARABIAN ETHICALS CO. |
| Retail Price | 57.50 AED |
Indications
Artamin Capsules (Hard Gelatin) is used for:
For treatment of Wilson's disease, cystinuria and active rheumatoid arthritis.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Penicillamine-d :
Mechanism of Action
Penicillamine is a chelating agent recommended for the removal of excess copper in patients with Wilson's disease. From in vitro studies which indicate that one atom of copper combines with two molecules of penicillamine. Penicillamine also reduces excess cystine excretion in cystinuria. This is done, at least in part, by disulfide interchange between penicillamine and cystine, resulting in formation of penicillamine-cysteine disulfide, a substance that is much more soluble than cystine and is excreted readily. Penicillamine interferes with the formation of cross-links between tropocollagen molecules and cleaves them when newly formed. The mechanism of action of penicillamine in rheumatoid arthritis is unknown although it appears to suppress disease activity. Unlike cytotoxic immunosuppressants, penicillamine markedly lowers IgM rheumatoid factor but produces no significant depression in absolute levels of serum immunoglobulins. Also unlike cytotoxic immunosuppressants which act on both, penicillamine in vitro depresses T-cell activity but not B-cell activity.
Note
Artamin 250mg Capsules (Hard Gelatin) manufactured by BIOCHEMIE GmbH. Its generic name is Penicillamine-d. Artamin is availble in United Arab Emirates.
Farmaco UAE drug index information on Artamin Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.