Atacand Tablets
Candesartan Cilexetil
4mg
ASTRAZENECA AB
| Pack size | 100's Bottle |
|---|---|
| Dispensing mode | POM |
| Source | SWEDEN |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 231.00 AED |
Available as:
Indications
Atacand Tablets is used for:
Hypertension, Congestive heart failure
Adult Dose
Oral
Hypertension
Adult: Initially, 8 mg once daily adjusted according to response. Maintenance: 8 mg once daily. Max: 32 mg/day as single or in 2 divided doses. Patients w/ intravascular volume depletion: Initially, 4 mg once daily.
Heart failure
Adult: Initially, 4 mg once daily, may be doubled at intervals of not <2 wk. Max: 32 mg once daily.
Hepatic impairment: Mild to moderate: Initially, 4 mg once daily. Severe: Contraindicated.
Child Dose
Oral
Hypertension
Child: 1 to <6 yr Initially, 200 mcg/kg/day. May increase according to response to 50-400 mcg/kg/day.
>6 yr <50 kg: 4-8 mg/day, adjusted according to response to 2-16 mg/day;
>50 kg: 8-16 mg/day, adjusted according response to 4-32 mg/day.
All doses may be given as single or in 2 divided doses.
Renal Dose
Renal Impairment
No dose adjustment necessary for patients with mild renal impairment
Initiate thearpy at lower dose if moderate renal impairment
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity. Pregnancy (2nd and 3rd trimester) and lactation.
Precautions
Volume or sodium depletion, preexisting renal insufficiency; aortic or mitral valve stenosis, hypertrophic obstructive cardiomyopathy, renal artery stenosis, primary hyperaldosteronism. Patients with a history of angioedema, urticaria. Monitor serum potassium levels especially in elderly and renally impaired patients. Hypotension may occur during major surgery and anaesthesia due to suppression of the renin-angiotensin system.
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: Not known if excreted in breast milk; not recommended
Pregnancy-Lactation
Pregnancy Category: D
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: Not known if excreted in breast milk; not recommended
Interactions
NSAIDs may reduce antihypertensive effect and result in deterioration of renal function including possible acute renal failure. May increase serum lithium concentration. K-sparing diuretics, K supplements or salt substitutes containing K may increase risk of hyperkalaemia.
Potentially Fatal: Coadministration w/ aliskiren in diabetic patients may increase risk of renal impairment, hypotension and hyperkalaemia.
Adverse Effects
Side effects of Candesartan Cilexetil :
Dizziness, headache, vertigo, back pain, upper resp tract infections, pharyngitis, rhinitis, hypotension, hyperkalaemia, increased serum creatinine.
Mechanism of Action
Candesartan inhibits the binding of angiotensin II to AT1 receptors in many tissues (e.g. vascular smooth muscles, adrenal gland) which leads to vasoconstriction blockade and aldosterone release.
Note
Atacand 4mg Tablets manufactured by ASTRAZENECA AB. Its generic name is Candesartan Cilexetil. Atacand is availble in United Arab Emirates.
Farmaco UAE drug index information on Atacand Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.