Baneocin Ointment

Bacitracin zinc, Neomycin sulfate
"250 IU, 5000 IU/g"
Sandoz GmbH
Pack size 20g Tube
Dispensing mode POM
Source AUSTRIA
AgentARABIAN ETHICALS CO.
Retail Price 9.00 AED

Indications

Baneocin Ointment is used for: BACITRACIN
For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin's inhibition of protein disulfide isomerase has been called into question
NEOMYCIN
Topical uses include treatment for superficial eye infections caused by susceptible bacteria (used in combination with other antiinfectives), treatment of otitis externa caused by susceptible bacteria, treatment or prevention of bacterial infections in skin lesions, and use as a continuous short-term irrigant or rinse to prevent bacteriuria and gram negative rod bacteremia in abacteriuric patients with indwelling catheters. May be used orally to treat hepatic encephalopathy, as a perioperative prophylactic agent, and as an adjunct to fluid and electrolyte replacement in the treatment of diarrhea caused to enteropathogenic e. Coli (epec)

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Bacitracin zinc, Neomycin sulfate :

Mechanism of Action

BACITRACIN
Bacitracin intereferes with the dephosphorylation of the 55-carbon, biphosphate lipid transport molecule c55-isoprenyl pyrophosphate (undecaprenyl pyrophosphate), which carries the building blocks of the peptidoglycan bacterial cell wall outside the inner membrane for construction. Bacitracin binds divalent transition metal ions (mn(ii), co(ii), ni(ii), cu(ii), and zn(ii)) which binds and oxidatively cleave dna
NEOMYCIN
Aminoglycosides like neomycin "irreversibly" bind to specific 30s-subunit proteins and 16s rrna. Specifically neomycin binds to four nucleotides of 16s rrna and a single amino acid of protein s12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16s rrna of 30s subunit. This region interacts with the wobble base in the anticodon of trna. This leads to interference with the initiation complex, misreading of mrna so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes

Note

Baneocin "250 IU, 5000 IU/g" Ointment manufactured by Sandoz GmbH. Its generic name is Bacitracin zinc, Neomycin sulfate. Baneocin is availble in United Arab Emirates. Farmaco UAE drug index information on Baneocin Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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