Bepro Syrup / Cough
Papaverine HCl, Codeine sulphate, Calcium Iodide, Glycerine
"0.625mg, 6.25mg, 1g, 50mg/5ml"
WALLACE (MFG. CHEMISTS LTD.)
| Pack size | 75ml |
|---|---|
| Dispensing mode | POM-R (Dispense maximum for one month) |
| Source | UK |
| Agent | ARABIAN ETHICALS CO. |
| Retail Price | 7.00 AED |
Indications
Bepro Syrup / Cough is used for:
PAPAVERINE
For the treatment of impotence and vasospasms
CODEINE
For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant
For the treatment of impotence and vasospasms
CODEINE
For treatment and management of pain (systemic). It is also used as an antidiarrheal and as a cough suppressant
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Papaverine HCl, Codeine sulphate, Calcium Iodide, Glycerine :
Mechanism of Action
PAPAVERINE
Perhaps by its direct vasodilating action on cerebral blood vessels, papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy
CODEINE
Opiate receptors are coupled with g-protein receptors and function as both positive and negative regulators of synaptic transmission via g-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of gtp for gdp on the g-protein complex. As the effector system is adenylate cyclase and camp located at the inner surface of the plasma membrane, opioids decrease intracellular camp by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance p, gaba, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close n-type voltage-operated calcium channels (op2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (op3 and op1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability
Perhaps by its direct vasodilating action on cerebral blood vessels, papaverine increases cerebral blood flow and decreases cerebral vascular resistance in normal subjects; oxygen consumption is unaltered. These effects may explain the benefit reported from the drug in cerebral vascular encephalopathy
CODEINE
Opiate receptors are coupled with g-protein receptors and function as both positive and negative regulators of synaptic transmission via g-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of gtp for gdp on the g-protein complex. As the effector system is adenylate cyclase and camp located at the inner surface of the plasma membrane, opioids decrease intracellular camp by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance p, gaba, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Codeine's analgesic activity is, most likely, due to its conversion to morphine. Opioids close n-type voltage-operated calcium channels (op2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (op3 and op1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability
Note
Bepro "0.625mg, 6.25mg, 1g, 50mg/5ml" Syrup / Cough manufactured by WALLACE (MFG. CHEMISTS LTD.). Its generic name is Papaverine HCl, Codeine sulphate, Calcium Iodide, Glycerine. Bepro is availble in United Arab Emirates.
Farmaco UAE drug index information on Bepro Syrup / Cough is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.