Bifril Plus Tablets / Film-coated
Hydrochlorothiazide, Zofenopril Calcium
"12.5mg, 30mg"
MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG SA
| Pack size | 28's (14's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | LUXEMBOURG |
| Agent | PHARMAWORLD |
| Retail Price | 70.00 AED |
Indications
Bifril Plus Tablets / Film-coated is used for:
Hydrochlorothiazide
For the treatment of high blood pressure and management of edema.
For the treatment of high blood pressure and management of edema.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Hydrochlorothiazide, Zofenopril Calcium :
Mechanism of Action
Hydrochlorothiazide
Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.
Hydrochlorothiazide, a thiazide diuretic, inhibits water reabsorption in the nephron by inhibiting the sodium-chloride symporter (SLC12A3) in the distal convoluted tubule, which is responsible for 5% of total sodium reabsorption. Normally, the sodium-chloride symporter transports sodium and chloride from the lumen into the epithelial cell lining the distal convoluted tubule. The energy for this is provided by a sodium gradient established by sodium-potassium ATPases on the basolateral membrane. Once sodium has entered the cell, it is transported out into the basolateral interstitium via the sodium-potassium ATPase, causing an increase in the osmolarity of the interstitium, thereby establishing an osmotic gradient for water reabsorption. By blocking the sodium-chloride symporter, hydrochlorothiazide effectively reduces the osmotic gradient and water reabsorption throughout the nephron.
Note
Bifril Plus "12.5mg, 30mg" Tablets / Film-coated manufactured by MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG SA. Its generic name is Hydrochlorothiazide, Zofenopril Calcium. Bifril Plus is availble in United Arab Emirates.
Farmaco UAE drug index information on Bifril Plus Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.