BOTOX Injection
Botulinum antitoxin
100 U
ALLERGAN PHARMACEUTICALS (IRELAND) LTD.
| Pack size | 1 Vial |
|---|---|
| Dispensing mode | POM |
| Source | IRELAND |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 990.50 AED |
Indications
BOTOX Injection is used for:
Botulism, Antitoxin indicated for naturally occurring noninfant botulism
Adult Dose
Botulism
Antitoxin indicated for naturally occurring noninfant botulism
IV solution
20 mL (1 vial) IV infusion; dilute further with 0.9% NaCl to 1:10 ratio before administering
Child Dose
Renal Dose
Administration
Administer slowly by IV infusion via volumetric infusion pump; minimize allergic reactions by starting at 0.5 mL/min for initial 30 minutes
If no infusion-related reaction, may increase to 1 mL/min IV for next 30 minutes, then if no reaction evident, may increase to 2 mL/min for remainder of infusion
IV Preparation
Thaw frozen antitoxin in water bath at 37C (99F)
Prepare infusion under aseptic conditions
Avoid foaming; do NOT shake vial
Visually assess for particulate matter and discoloration
Do not use unless solution is clear, nonturbid, and without particulate matter
Dilute 1:10 in 0.9% NaCl for injection
May store premixed IV bag refrigerated; use within 8-10 hr
IV Administration
In-line filter optional; pore size no smaller than 15 microns (smaller pore size may slow infusion rate)
Administer slowly by IV infusion via volumetric infusion pump; minimize allergic reactions by starting at 0.5 mL/min for initial 30 minutes
If no infusion-related reaction, may increase to 1 mL/min IV for next 30 minutes, then if no reaction evident, may increase to 2 mL/min for remainder of infusion
Epinephrine, diphenhydramine, and intubation capabilities must be immediately available to treat anaphylaxis
Contra Indications
No absolute contraindications identified in individual with high-risk exposure to botulinum toxin
Precautions
Allergic reactions are expected to be infrequent
Immediate systemic reactions (allergic reactions, shock, anaphylaxis) can occur whenever an equine product is administered; immediate reaction usually occurs within 30 minutes after initiating infusion
Infuse IV slowly as described under administration in adult dosing section
Milder allergic reactions (eg, mild bronchoconstriction, hypotension, hives) may be more common
Pregnancy-Lactation
Pregnancy Category: C; experience limited in pregnant women; however, A, B and E antitoxins have been given to pregnant women without causing harm to the mother or the fetus
Being pregnant is not a reason to avoid H-BAT administration for botulism; benefit to the mother and the fetus from receiving heptavalent botulinum antitoxin should be weighed against risk of harm from treatment; decisions should be made on a case-by-case basis by treating physician
Lactation: Unknown whether distributed in breast milk
Interactions
Adverse Effects
Side effects of Botulinum antitoxin :
Investigational IND, adverse drug reactions unknown
Mechanism of Action
Equine derived antitoxin that elicits passive antibody (ie, immediate immunity) against Clostridium botulinum toxins A, B, C, D, E, F, and G
Note
BOTOX 100 U Injection manufactured by ALLERGAN PHARMACEUTICALS (IRELAND) LTD.. Its generic name is Botulinum antitoxin. BOTOX is availble in United Arab Emirates.
Farmaco UAE drug index information on BOTOX Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.