Bronchophane Syrup
Dextromethorphan (as HBr), Diphenhydramine HCl, Ephedrine HCl, Guaiphenesin
"4.58mg, 5mg, 7.5mg, 50mg/5ml"
Egyptian International Pharmaceutical Industries Co. (E.I.P.I.Co.)
| Pack size | 125ml Bottle |
|---|---|
| Dispensing mode | POM-R (Dispense maximum for one month) |
| Source | EGYPT |
| Agent | PHARMATRADE |
| Retail Price | 10.50 AED |
Indications
Bronchophane Syrup is used for:
DEXTROMETHORPHAN
For treatment and relief of dry cough
DIPHENHYDRAMINE
For the treatment of symptoms associated with vertigo/meniere's disease, nausea and vomiting, motion sickness and insect bite
EPHEDRINE
Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia
GUAIFENESIN
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections
For treatment and relief of dry cough
DIPHENHYDRAMINE
For the treatment of symptoms associated with vertigo/meniere's disease, nausea and vomiting, motion sickness and insect bite
EPHEDRINE
Ephedrine commonly used as a stimulant, appetite suppressant, concentration aid, decongestant, and to treat hypotension associated with anaesthesia
GUAIFENESIN
Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dextromethorphan (as HBr), Diphenhydramine HCl, Ephedrine HCl, Guaiphenesin :
Mechanism of Action
DEXTROMETHORPHAN
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the nmda glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan
DIPHENHYDRAMINE
Diphenhydramine competes with free histamine for binding at ha-receptor sites. This antagonizes the effects of histamine on ha-receptors, leading to a reduction of the negative symptoms brought on by histamine ha-receptor binding
EPHEDRINE
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic a-receptors and ?-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action
GUAIFENESIN
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the nmda glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan
DIPHENHYDRAMINE
Diphenhydramine competes with free histamine for binding at ha-receptor sites. This antagonizes the effects of histamine on ha-receptors, leading to a reduction of the negative symptoms brought on by histamine ha-receptor binding
EPHEDRINE
Ephedrine is a sympathomimetic amine - that is, its principal mechanism of action relies on its direct and indirect actions on the adrenergic receptor system, which is part of the sympathetic nervous system. Ephedrine increases post-synaptic noradrenergic receptor activity by (weakly) directly activating post-synaptic a-receptors and ?-receptors, but the bulk of its effect comes from the pre-synaptic neuron being unable to distinguish between real adrenaline or noradrenaline from ephedrine. The ephedrine, mixed with noradrenaline, is transported through the noradrenaline reuptake complex and packaged (along with real noradrenaline) into vesicles that reside at the terminal button of a nerve cell. Ephedrine's action as an agonist at most major noradrenaline receptors and its ability to increase the release of both dopamine and to a lesser extent, serotonin by the same mechanism is presumed to have a major role in its mechanism of action
GUAIFENESIN
Guaifenesin may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing
Note
Bronchophane "4.58mg, 5mg, 7.5mg, 50mg/5ml" Syrup manufactured by Egyptian International Pharmaceutical Industries Co. (E.I.P.I.Co.). Its generic name is Dextromethorphan (as HBr), Diphenhydramine HCl, Ephedrine HCl, Guaiphenesin. Bronchophane is availble in United Arab Emirates.
Farmaco UAE drug index information on Bronchophane Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.