Buccastem Tablets / Buccal

Prochlorperazine Maleate
3mg
RECKITT & COLMAN
Pack size 50's (10's Blister x 5)
Dispensing mode POM
Source UK
AgentCITY MEDICAL STORE
Retail Price 34.00 AED

Indications

Buccastem Tablets / Buccal is used for: Vertigo, Psychoses, Nausea and vomiting, Severe anxiety disorders

Adult Dose

Oral Prophylaxis of nausea and vomitting Adult: As maleate : 5-10 mg bid/tid. Nausea and vomiting Adult: As maleate : 20 mg, further doses are given if needed. Recommended buccal dose: As maleate: 3-6 mg bid. Psychoses Adult: As maleate : 12.5 mg bid for 7 days, adjusted gradually to 75-100 mg daily according to response. Usual maintenance dose: 25-50 mg daily. Adjunct in severe anxiety disorders Adult: As maleate: 5-10 mg, up to 3-4 times daily. Vertigo Adult: As maleate : 15-30 mg daily, given in divided doses. May reduce gradually to 5-10 mg daily. Recommended buccal dose: 3-6 mg bid.

Child Dose

Oral Psychoses Child: 1-5 yr: 1.25-2.5 mg; 5-12 yr: 2.5-5 mg. May be given up to tid, if necessary.

Renal Dose

Administration

May be taken with or without food.

Contra Indications

CNS depression, comatose patients. Bone marrow depression, phaechromocytoma, prolactin-dependent tumours, hypersensitivity. Childn <2 yr. Pregnancy and lactation.

Precautions

Extrapyramidal syndrome, hypotension, epilepsy, impaired hepatic, renal, CV, cerebrovascular or respiratory function, glaucoma. May impair ability to drive or perform tasks requiring mental alertness or physical coordination. Parenteral use in children is not recommended. History of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia or urinary retention. Regular eye examinations are recommended in patients on long-term treatment. Lactation: Phenothiazines may be excreted in breast milk; do not nurse

Pregnancy-Lactation

Pregnancy category: C Lactation: Phenothiazines may be excreted in breast milk; do not nurse

Interactions

Additive anticholinergic effects with antihistamines, tricyclic antidepressants and drugs used in parkinsonism. May reduce the antihypertensive effect of guanethidine and other adrenergic neurone blockers. May also increase risk of arrhythmias when used with drugs that prolong QT interval. Potentially Fatal: Potentiation of other CNS depressants including alcohol, sedatives, hypnotics, barbiturates, opioids, antihistamines and general anaesthetics.

Adverse Effects

Side effects of Prochlorperazine Maleate : <1% Insomnia, Restlessness, Dizziness, Anxiety, Euphoria, Agitation, Depression, Weakness, Headache, Cerebral edema, Poikilothermia, Tachycardia, ECG changes, Anorexia, Dyspepsia, Constipation, Diarrhea, Ileus, Blood dyscrasia, Galactorrhea, Gynecomastia, Ejaculatory disorder, Lens opacities (with prolonged use), Photosensitivity, Pruritus Frequency Not Defined Akathisia, Sedation, Anticholinergic effects, Weight gain, Oligomenorrhea or amenorrhea, Erectile dysfunction, Extrapyramidal symptoms (muscle stiffness, dystonia, parkinsonism, tardive dyskinesia), Neuroleptic malignant syndrome (infrequent but serious), Seizure, Decreased gag reflex, Confusion, Hypotension, Hypertension, Leukopenia, Agranulocytosis, Cholestatic jaundice, Photosensitivity reaction, Priapism, Hepatotoxicity Potentially Fatal: Bone-marrow suppression. Cardiac arrhythmias or aspiration.

Mechanism of Action

Prochlorperazine blocks both postsynaptic dopamine receptors as well as the medullary chemo receptor trigger zone. It depresses hypothalamic and hypophyseal hormone release and posssesses alpha-adrenergic and anticholinergic inhibitory activity.

Note

Buccastem 3mg Tablets / Buccal manufactured by RECKITT & COLMAN. Its generic name is Prochlorperazine Maleate. Buccastem is availble in United Arab Emirates. Farmaco UAE drug index information on Buccastem Tablets / Buccal is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Prochlorperazine Maleate :