Cardura Tablets
Doxazosin
1mg
HEINRICH MACK NACHF (SUBSIDIARY OF PFIZER)
| Pack size | 20's (2 x 10's Blister) |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 31.00 AED |
Available as:
Indications
Cardura Tablets is used for:
Hypertension, Benign Prostatic Hyperplasia
Adult Dose
Oral
Hypertension
Adult: Initially, 1 mg at bedtime, may be doubled at 1-2 wk intervals according to response. Maintenance: Up to 4 mg once daily. Max: 16 mg/day.
Extended-release: Initially, 4 mg once daily, may increase to max 8 mg once daily after 4 wk.
Benign prostatic hyperplasia
Adult: Initially, 1 mg at bedtime, may be doubled at 1-2 wk intervals according to response. Maintenance: 2-4 mg/day. Max: 8 mg/day.
Extended-release: Initially, 4 mg once daily, may increase to max 8 mg once daily after 4 wk.
Hepatic impairment: Use with caution in mild-to-moderate hepatic dysfunction; do not use in severe impairment
Child Dose
Renal Dose
Administration
May be taken with or without food. Give first dose and increase at bedtime to avoid syncope
Contra Indications
Patient w/ history of orthostatic hypotension; benign prostatic hyperplasia and concomitant congestion of the upper urinary tract, chronic urinary tract infection or bladder stones; monotherapy in patients w/ either overflow bladder or anuria w/ or w/o progressive renal insufficiency.
Precautions
Prostatic carcinoma should be ruled out before starting therapy. Hepatic impairment. Pregnancy and lactation. Patient Counselling May impair ability to drive and operate machinery. Monitoring Parameters Monitor BP and renal function.
Lactation: Unknown whether drug is excreted in milk; use with caution
Pregnancy-Lactation
Pregnancy
Not indicated for use in females or for the treatment of hypertension; the limited available data in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage; no adverse developmental outcomes were observed in animal reproduction studies with oral administration to pregnant rats and rabbits at doses of up to 10 and 4 times, respectively, the 12 mg/day recommended dose; postnatal development was delayed in rats at a dose of 8 times the 12 mg/day recommended dose
Lactation
Present in human milk; there is no information on effects on breastfed infant or effects on milk production
Interactions
Concomitant admin w/ phosphodiesterase type 5 (PDE-5) inhibitors (e.g. sildenafil) may lead to symptomatic hypotension. Potentiates the BP lowering activity of other α-blockers and other antihypertensives.
Adverse Effects
Side effects of Doxazosin :
>10%
Dizziness (5-19%), Fatigue (8-12%), Headache (6-10%)
1-10%
Vertigo (7%), Upper respiratory tract infection (URTI) (5%), Edema (3-4%), Rhinitis (3%), Dyspnea (1-3%), Abdominal pain (2%), Hypotension (1-2%), Nausea (1-2%), Orthostatic hypotension (dose related) (0.3-2%), Anxiety (1%), Palpitations (1%)
Mechanism of Action
Hypertension: Blocks postsynaptic alpha1 receptors; alpha blockade causes arterial, arteriolar, and venous dilation; decreases total peripheral resistance and blood pressure
Benign prostatic hyperplasia (BPH): Blocks alpha1 receptors in prostatic stromal and bladder tissues; reduces sympathetic tone-induced urethral stricture responsible for BPH symptoms
Note
Cardura 1mg Tablets manufactured by HEINRICH MACK NACHF (SUBSIDIARY OF PFIZER). Its generic name is Doxazosin. Cardura is availble in United Arab Emirates.
Farmaco UAE drug index information on Cardura Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.