Cefadrox Suspension

Cefadroxil
250mg/5ml
Jazeera Pharmaceutical Industries
Pack size 100ml Plastic Bottle
Dispensing mode POM
Source SAUDI ARABIA
AgentGULF DRUG EST.
Retail Price 11.00 AED

Available as:

500mg/5ml - Suspension 500mg - Capsules (Hard Gelatin)

Indications

Cefadrox Suspension is used for: Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection, Skin infections

Adult Dose

Oral Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections Adult: 1-2 g daily as a single or in 2 divided doses. Hepatic impairment: No dosage adjustment needed.

Child Dose

Oral Tonsillitis; Skin and skin structure infections; Streptococcal pharyngitis; Urinary tract infections Child: >6 yr <40 kg: 30-50 mg/kg daily as a single or in 2 divided doses, up to 100 mg/kg daily.

Renal Dose

Renal impairment: CrCl (ml/min) 26-50 0.5-1 g bid. 11-25 0.5-1 g once daily. <10 0.5-1 g every 36 hr.

Administration

May be taken with or without food. May be taken w/ meals to reduce GI discomfort.

Contra Indications

Hypersensitivity to cephalosporins.

Precautions

Impaired renal function; pregnancy and lactation. Lactation: enters breast milk; use with caution

Pregnancy-Lactation

Pregnancy Category: B Lactation: enters breast milk; use with caution

Interactions

Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.

Adverse Effects

Side effects of Cefadroxil : 1-10% Diarrhea <1% Abdominal pain, Dyspepsia, Nausea, Vomiting, Rash, Urticaria, Pseudomembranous colitis, Stevens-Johnson syndrome, Anaphylaxis, Transaminases increased, Neutropenia Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Mechanism of Action

Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.

Note

Cefadrox 250mg/5ml Suspension manufactured by Jazeera Pharmaceutical Industries. Its generic name is Cefadroxil. Cefadrox is availble in United Arab Emirates. Farmaco UAE drug index information on Cefadrox Suspension is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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