Celemac Capsules (Hard Gelatin)

Celecoxib
100mg
Macleods Pharmaceuticals Ltd.
Pack size 10's Blister
Dispensing mode POM
Source INDIA
AgentPHARMA HOUSE PHARMACEUTICALS L.L.C.
Retail Price 13.50 AED

Indications

Celemac Capsules (Hard Gelatin) is used for: Rheumatoid arthritis, Osteoarthritis, Ankylosing spondylitis, Dysmenorrhea, Acute pain, Familial adenomatous polyposis

Adult Dose

Oral Osteoarthritis Adult: 200 mg/day as a single dose or in 2 divided doses. May increase to 200 mg bid, if necessary. Rheumatoid arthritis Adult: 100-200 mg bid. Dysmenorrhoea; Pain relief Adult: Initially, 400 mg followed by 200 mg if necessary on the 1st day. Maintenance: 200 mg bid. Ankylosing spondylitis Adult: Initially, 200 mg/day as a single dose or in 2 divided doses. May increase to 400 mg/day after 6 wk. Hepatic impairment: Moderate (Child-Pugh category B): Reduce dose by 50%. Severe (Child-Pugh category C or ?10 score): Contraindicated.

Child Dose

Juvenile idiopathic arthritis Child: >2 yr >10 kg to <25 kg: 50 mg bid; >25 kg: 100 mg bid.

Renal Dose

Administration

May be taken with or without food. Dose for OA/RA may be given w/ or w/o meals, but doses for FAP must be given w/ meals.

Contra Indications

Hypersensitivity including those in whom attacks of angioedema, rhinitis and urticaria have been precipitated by aspirin, NSAIDs or sulfonamides. Severe hepatic impairment; severe heart failure; inflammatory bowel disease; peptic ulcer; renal impairment (creatinine clearance <30 mL/min); pregnancy and lactation.

Precautions

History of GI bleeding; renal/hepatic insufficiency; asthma or allergic disorders; hypertension; monitor Hb or haematocrit levels for signs of anaemia. History of cerebrovascular disease or ischaemic heart disease (IHD). Lactation: Drug enters breast milk; use caution

Pregnancy-Lactation

Pregnancy category: C; D at >30 weeks' gestation (may cause premature closure of ductus arteriosus) Lactation: Drug enters breast milk; use caution

Interactions

May increase plasma level w/ CYP2C9 isoenzymes (e.g. fluconazole). May increase serum level of lithium. May reduce effect of antihypertensives and diuretics. May increase anticoagulant effect of warfarin.

Adverse Effects

Side effects of Celecoxib : >10% Headache (10-16%), Hypertension (13%) 1-10% Fever (9%), Dyspepsia (8.8%), Upper respiratory tract infection (8.1%), Arthralgia (7%), Cough (7%), Vomiting (6%), Diarrhea (5.6%), Gastroesophageal reflux (5%), Sinusitis (5%), Abdominal pain (4.1%), Nausea (3.5%), Back pain (2.8%), Insomnia (2.3%), Pharyngitis (2.3%), Flatulence (2.2%), Rash (2.2%), Dizziness (2%), Peripheral edema (2%) <1% Anemia, Erythema multiforme, Exfoliative dermatitis, Hepatitis, Jaundice, Stevens-Johnson syndrome, Toxic epidermal necrolysis Frequency Not Defined Increased serum asparate aminotransferase concentration Potentially Fatal: Serious skin reactions such as exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis.

Mechanism of Action

Celecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor primarily responsible to reduce mediators of pain and inflammation. Its action is due to inhibition of prostaglandin synthesis via inhibition of COX-2.

Note

Celemac 100mg Capsules (Hard Gelatin) manufactured by Macleods Pharmaceuticals Ltd.. Its generic name is Celecoxib. Celemac is availble in United Arab Emirates. Farmaco UAE drug index information on Celemac Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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