Clottafact Infusion
Human Fibrinogen
1.5g/100ml
LFB BIOMEDICAMENTS
| Pack size | Powder in a vial (glass) + 100 ml of solvent in a vial (glass) with a stopper (halobutyl) |
|---|---|
| Dispensing mode | POM |
| Source | FRANCE |
| Agent | AL ITTIHAD DRUG STORE |
| Retail Price | 6242.50 AED |
Indications
Clottafact Infusion is used for:
For the treatment of acute bleeding episodes in patients with congenital fibrinogen deficiency, including afibrinogenemia and hypofibrinogenemia.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Human Fibrinogen :
Mechanism of Action
Fibrinogen (factor I) is a soluble plasma glycoprotein with a molecular weight of about 340 kDa. The native molecule is a dimer and consists of three pairs of polypeptide chains (Aa, B< and ?). Fibrinogen is a physiological substrate of three enzymes: thrombin, factor XIIIa, and plasmin. During the coagulation process, thrombin cleaves the Aa and B< chains releasing fibrinopeptides A and B (FPA and FPB, respectively). FPA is separated rapidly and the remaining molecule is a soluble fibrin monomer (fibrin I). The slower removal of FPB results in formation of fibrin II that is capable of polymerization that occurs by aggregation of fibrin monomers. The resulting fibrin is stabilized in the presence of calcium ions and by activated factor XIII, which acts as a transglutaminase. Factor XIIIa-induced cross-linking of fibrin polymers renders the fibrin clot more elastic and more resistant to fibrinolysis. Cross-linked fibrin is the end result of the coagulation cascade, and provides tensile strength to a primary hemostatic platelet plug and structure to the vessel wall.
Note
Clottafact 1.5g/100ml Infusion manufactured by LFB BIOMEDICAMENTS. Its generic name is Human Fibrinogen. Clottafact is availble in United Arab Emirates.
Farmaco UAE drug index information on Clottafact Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.