Co-Irbea 300/25 Tablets / Film-coated
Hydrochlorothiazide + Irbesartan
"300mg, 25mg"
Laboratorios Cinfa S.A
| Pack size | 28's (7's Blister x 4) |
|---|---|
| Dispensing mode | POM |
| Source | SPAIN |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 75.50 AED |
Indications
Co-Irbea 300/25 Tablets / Film-coated is used for:
Diabetic nephropathy, Hypertension
Adult Dose
Hypertension
150 mg/12.5 mg PO qDay intially; if needed, after 1-2 weeks may titrate up to 300 mg/25 mg PO qDay
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity; pregnancy and lactation.
Precautions
Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy.
Lactation: discontinue drug or do not nurse
Pregnancy-Lactation
Pregnancy Category: C (1st trimester); D (2nd & 3rd trimesters)
Lactation: discontinue drug or do not nurse
Interactions
Other antihypertensives, lithium, K-sparing diuretics, K supplements, salt substitutes containing K. CNS depressants, antidiabetics, cholestyramine & colestipol resins, corticosteroids, ACTH, digitalis glycosides, antiarrhythmics, NSAIDs, tubocurarine, antigout medications, Ca salts. Alcohol; ?-blockers, diazoxide, atropine, beperiden, amantadine, cyclophosphamide, methotrexate.
Adverse Effects
Side effects of Hydrochlorothiazide + Irbesartan :
>10%
Irbesartan
Hyperkalemia (19%)
1-10%
Chest pain (2%), Tachycardia (1%), Abnormal urination (2%), Musculoskeletal pain (6%), Flu-like syndrome (3%), Edema (3%), Tachycardia (1%), Chest pain (2%), Creatinine increased (1%), Increased BUN (2%)
Irbesartan
Dizziness (10%), URI (9%), Orthostatic hypotension (5%), Fatigue (4%), Diarrhea (3%), Dyspepsia (2%)
Frequency Not Defined
Hydrochlorothiazide
Anorexia, Epigastric distress, Hypotension, Orthostatic hypotension, Photosensitivity, Anaphylaxis, Anemia, Confusion, Erythema multiforme, Stevens-Johnson syndrome, Exfoliative dermatitis including toxic epidermal necrolysis, Dizziness, Hypokalemia and/or hypomagnesemia, Hyperuricemia, Headache
Mechanism of Action
Hydrochlorothiazide inhibits the reabsorption of Na and chloride in the distal tubules causing increased excretion of Na and water K and hydrogen ions.
Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.
Note
Co-Irbea 300/25 "300mg, 25mg" Tablets / Film-coated manufactured by Laboratorios Cinfa S.A. Its generic name is Hydrochlorothiazide + Irbesartan. Co-Irbea 300/25 is availble in United Arab Emirates.
Farmaco UAE drug index information on Co-Irbea 300/25 Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Some other brands of Hydrochlorothiazide + Irbesartan :
Tablets / Film-coated
Co-Irbea 150/12.5
"150mg, 12.5mg"
Laboratorios Cinfa S.A
Tablets / Film-coated
Co-Irbea 300/12.5
"300mg, 12.5mg"
Laboratorios Cinfa S.A
Tablets / Film-coated
Andaran Plus 150/12.5
"150mg, 12.5mg"
SANDOZ FARMACEUTICA S.A.
Tablets / Film-coated
Andaran Plus 300/12.5
"300mg, 12.5mg"
SANDOZ FARMACEUTICA S.A.
Tablets / Film-coated
Avansart H 150/12.5
"150mg, 12.5mg"
Neopharma