Coartil Tablet
Perindopril + Amlodipine
8mg/10mg
PHARMA BAVARIA INTERNACIONAL (PBI) PORTUGAL
| Pack size | 30's(30's Blister x 1) |
|---|---|
| Dispensing mode | MUSCAT PHARMACEUTICAL TRADING L.L.C. |
| Source | |
| Agent | PORTUGAL |
| Retail Price | 64.50 AED |
Available as:
Indications
Coartil Tablet is used for:
Indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled on monotherapy or as initial therapy in patients likely to need multiple drugs to achieve blood pressure goals
Adult Dose
Hypertension
Indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled on monotherapy or as initial therapy in patients likely to need multiple drugs to achieve blood pressure goals
Tablet
4 mg/5 mg PO qDay with or without food
Adjust dose according to blood pressure goals; wait 7-14 days between titration steps
Not to exceed 14 mg/10 mg qDay
Hepatic impairment: There are no data to guide dosing recommendations
Child Dose
Renal Dose
Renal Impairment
CrCl <30 mL/min: Not recommended
CrCl 30-80 mL/min (mild or moderate renal impairment): Do not exceed 7/5 mg
Administration
Should be taken on an empty stomach.
Contra Indications
History of idiopathic angioedema. Severe hypotension, shock (e.g. cardiogenic shock), left ventricular outflow tract obstruction (e.g. high grade aortic stenosis), heart failure after acute MI. Pregnancy and lactation. Concomitant use w/ aliskiren esp in patients w/ DM or renal impairment (GFR <30 mL/min/1.73 m2).
Precautions
Patient w/ salt or volume depletion, severe obstructive coronary artery disease, renal artery and mitral and severe aortic stenosis, ischemic heart disease or cerebrovascular disease, hypertrophic cardiomyopathy w/ outflow tract obstruction, cardiac failure, collagen vascular disease. Hepatic and renal impairment. Elderly. Patient undergoing major surgery or during anaesthesia; desensitisation treatment (e.g. hymenoptera venom).
Lactation: Unknown if distributed in human breast milk; because of the potential for adverse effects on the nursing infant, decide whether to discontinue nursing or discontinue the drug
Pregnancy-Lactation
Pregnancy Category: D
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: Unknown if distributed in human breast milk; because of the potential for adverse effects on the nursing infant, decide whether to discontinue nursing or discontinue the drug
Interactions
Increased hypotensive effects w/ antihypertensive agents (e.g. β-blockers), diuretics, and vasodilators. May increase serum levels and toxicity of lithium. May cause nitritoid reactions w/ Na aurothiomalate. Increased risk of angioneurotic oedema w/ estramustine. May increase hypoglycaemic effect w/ insulin or sulfonamides. Increased antihypertensive effect and risk of orthostatic hypotension w/ TCAs, antipsychotics, anaesthetics, α-blockers. May increase risk of angioedema w/ mammalian target of rapamycin (mTOR) inhibitors (e.g. sirolimus, everolimus, temsirolimus). May cause worsening of renal function and loss of antihypertensive effect w/ NSAIDs. Decreased antihypertensive effects w/ NSAIDs and sympathomimetics.
Adverse Effects
Side effects of Perindopril + Amlodipine :
1-10%
Peripheral edema (7.2%)
Cough (3.2%)
Headache (2.5%)
Dizziness (2.5%)
Frequency Not Defined
Dermatologic: Rash
Digestive: Nausea, diarrhea
Mechanism of Action
Perindopril, a prodrug of perindoprilat, is an ACE inhibitor which prevents convertion of angiotensin I to angiotensin II, thereby increasing plasma renin activity and decreasing vasoconstriction and aldosterone secretion.
Amlodipine, a dihydropyridine Ca channel blocker, inhibits transmembrane influx of Ca ions into vascular smooth muscle and cardiac muscle thereby causing relaxation and vasodilation. It also directly acts on vascular smooth muscle causing reductions in peripheral vascular resistance and BP.
Note
Coartil 8mg/10mg Tablet manufactured by PHARMA BAVARIA INTERNACIONAL (PBI) PORTUGAL. Its generic name is Perindopril + Amlodipine. Coartil is availble in United Arab Emirates.
Farmaco UAE drug index information on Coartil Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.
Some other brands of Perindopril + Amlodipine :
Tablets
Coveram 10mg/10mg
"10mg, 10mg"
SERVIER (IRELAND) INDUSTRIES LTD.
Tablets
Coveram 10mg/5mg
"10mg, 5mg"
SERVIER (IRELAND) INDUSTRIES LTD.
Tablets
Coveram 5mg/10mg
"5mg, 10mg"
SERVIER (IRELAND) INDUSTRIES LTD.
Tablets
Coveram 5mg/5mg
"5mg, 5mg"
SERVIER (IRELAND) INDUSTRIES LTD.
Tablet
Coartil Plus
4mg/10mg
PHARMA BAVARIA INTERNACIONAL (PBI) PORTUGAL