Cobal 500mcg Tablets / Film-coated

Mecobalamin
500mcg
The Jordanian Pharmaceutical Manufacturing Company
Pack size 30's (15's Blister x 2)
Dispensing mode P
Source JORDAN
AgentDUPHARM L.L.C
Retail Price 25.00 AED

Indications

Cobal 500mcg Tablets / Film-coated is used for: Megaloblastic anaemia, Peripheral neuropathies

Adult Dose

Oral Peripheral neuropathies Adult: 1500 mcg/day in 3 divided doses. Parenteral Peripheral neuropathies Adult: 500 mcg daily IM/IV 3 times/wk. Megaloblastic anaemia caused by vitamin B12 deficiency Adult: 500 mcg daily IM/IV 3 times/wk. Maintenance dose: After about 2 mth of therapy, reduce dose to single admin of 500 mcg every 1-3 mth.

Child Dose

Renal Dose

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity to any component of this product.

Precautions

The medicine should not be used for months if there is no response at all after its use for a certain period of time.

Pregnancy-Lactation

Interactions

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Adverse Effects

Side effects of Mecobalamin : Oral: Anorexia, nausea, vomiting and diarrhoea. Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site. Potentially Fatal: Anaphylactoid reactions (parenteral).

Mechanism of Action

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Note

Cobal 500mcg 500mcg Tablets / Film-coated manufactured by The Jordanian Pharmaceutical Manufacturing Company. Its generic name is Mecobalamin. Cobal 500mcg is availble in United Arab Emirates. Farmaco UAE drug index information on Cobal 500mcg Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Mecobalamin :