Coldex-D Syrup
Cold & Cough - Chlorpheniramine maleate, Dextromethorphan HBr, Glyceryl guaiacolate, Pseudoephedrine HCl
"1.25mg, 10mg, 50mg, 30mg/5ml"
The Arab Parm. Mfg. Co (APM)
| Pack size | 100ml Bottle |
|---|---|
| Dispensing mode | POM-R (Dispense maximum for one month) |
| Source | JORDAN |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 6.00 AED |
Indications
Coldex-D Syrup is used for:
PHENIRAMINE
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria
DEXTROMETHORPHAN
For treatment and relief of dry cough
PSEUDOEPHEDRINE
For the treatment of nasal congestion, sinus congestion, eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria
DEXTROMETHORPHAN
For treatment and relief of dry cough
PSEUDOEPHEDRINE
For the treatment of nasal congestion, sinus congestion, eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Cold & Cough - Chlorpheniramine maleate, Dextromethorphan HBr, Glyceryl guaiacolate, Pseudoephedrine HCl :
Mechanism of Action
PHENIRAMINE
Antihistamines such as pheniramine appear to compete with histamine for histamine h1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of h1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for h1-receptors
DEXTROMETHORPHAN
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the nmda glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan
PSEUDOEPHEDRINE
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors
Antihistamines such as pheniramine appear to compete with histamine for histamine h1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of h1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for h1-receptors
DEXTROMETHORPHAN
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the nmda glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan
PSEUDOEPHEDRINE
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors
Note
Coldex-D "1.25mg, 10mg, 50mg, 30mg/5ml" Syrup manufactured by The Arab Parm. Mfg. Co (APM). Its generic name is Cold & Cough - Chlorpheniramine maleate, Dextromethorphan HBr, Glyceryl guaiacolate, Pseudoephedrine HCl. Coldex-D is availble in United Arab Emirates.
Farmaco UAE drug index information on Coldex-D Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.