COLIRCUSI DEXAMETHASONE CONSTRICTOR Eye Drops

Chloramphenicol (sodium succinate), Dexamethasone Sodium phosphate, Tetryzoline HCl
Combination
Cusi Laboratories
Pack size 10ml Dropper Bottle
Dispensing mode POM
Source SPAIN
AgentAL HAYAT PHARMACEUTICALS
Retail Price 5.50 AED

Indications

COLIRCUSI DEXAMETHASONE CONSTRICTOR Eye Drops is used for: CHLORAMPHENICOL
Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis
DEXAMETHASONE
injection: for the treatment of endocrine disorders, rheumatic d=disorders, collagen diseases, dermatologic diseases, allergic statesc, ophthalmic diseases, gastrointestinal diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, cerebral edema.
ophthalmic ointment and solution: for the treatment of steroid responsive inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe.
ophthalmic solution only: for the treatment of steroid responsive inflammatory conditions of the external auditory meatus
topic cream: for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses
oral aerosol: for the treatment of bronchial asthma and related corticosteroid responsive bronchospastic states intractable to adequate trial of conventional therapy
intranasal aerosol: for the treatment of allergic ot inflammatory nasal conditions, and nasal polyps

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chloramphenicol (sodium succinate), Dexamethasone Sodium phosphate, Tetryzoline HCl :

Mechanism of Action

CHLORAMPHENICOL
Chloramphenicol is lipid-soluble, allowing it to diffuse through the bacterial cell membrane. It then reversibly binds to the l16 protein of the 50s subunit of bacterial ribosomes, where transfer of amino acids to growing peptide chains is prevented (perhaps by suppression of peptidyl transferase activity), thus inhibiting peptide bond formation and subsequent protein synthesis
DEXAMETHASONE
Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to dna elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase a2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes

Note

COLIRCUSI DEXAMETHASONE CONSTRICTOR Combination Eye Drops manufactured by Cusi Laboratories. Its generic name is Chloramphenicol (sodium succinate), Dexamethasone Sodium phosphate, Tetryzoline HCl. COLIRCUSI DEXAMETHASONE CONSTRICTOR is availble in United Arab Emirates. Farmaco UAE drug index information on COLIRCUSI DEXAMETHASONE CONSTRICTOR Eye Drops is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chloramphenicol (sodium succinate), Dexamethasone Sodium phosphate, Tetryzoline HCl :