Colpermin Capsules (Hard Gelatin) / Enteric-coated

Pepermint oil
187mg
TILLOTS PHARMA AG
Pack size 100's (10's Blister x 10)
Dispensing mode P
Source SWITZERLAND
AgentAL HAYAT PHARMACEUTICALS
Retail Price AED

Indications

Colpermin Capsules (Hard Gelatin) / Enteric-coated is used for: Indicated for the over-the-counter use for: -the symptomatic relief of minor spasms of the gastrointestinal tract, flatulence and abdominal pain, especially in patients with irritable bowel syndrome. -the temporary relief of itching associated with insect bites, eczema, minor burn, sunburn, minor skin irritations, minor cuts, scrapes, atopic dermatitis and other skin disorders. -the temporary symptomatic relief of mild joint and muscle pain as a local topical analgesic. -the temporary relief of tension-type headache.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Pepermint oil :

Mechanism of Action

Dose-dependent antispasmodic effect of peppermint oil is largely mediated by its menthol constituent [A33056]. It is proposed that peppermint oil relaxes gastrointestinal smooth muscle and attenuates contractile responses by reducing the influx of extracellular calcium ions. In rabbit jejunum smooth muscle cells investigated via whole cell clamp configuration technique, peppermint oil was shown to inhibit the potential-dependent calcium currents in a concentration-dependent manner [A33056]. Both a reduction in peak current amplitude and an increase in the rate of current decay were observed, indicating that the pharmacological activity peppermint oil resembles that of dihydropyridine calcium antagonists [A33056]. In a rat small intestine study, peppermint oil in the intestinal lumen inhibited enterocyte glucose uptake via a direct action on the brush border membrane and inhibited intestinal secretion [A33056]. There is also evidence that menthol is an antagonist of L-type Ca2+ channels via interacting with dihydropyridine binding sites and blocks the currents of low-voltage-activated calcium channels [A33056]. Peppermint oil may facilitate hair growth by promoting the conservation of vascularization of hair dermal papilla, which may contribute to the induction of early anagen stage of active growth phase of hair follicles [A33044].

Note

Colpermin 187mg Capsules (Hard Gelatin) / Enteric-coated manufactured by TILLOTS PHARMA AG. Its generic name is Pepermint oil. Colpermin is availble in United Arab Emirates. Farmaco UAE drug index information on Colpermin Capsules (Hard Gelatin) / Enteric-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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