Cyanokit Infusion
Hydroxocobalamin
5g
SERB SA
| Pack size | 1 Vial + 1 sterile transfer device + 1 sterile intravenous infusion set + 1 sterile short catheter |
|---|---|
| Dispensing mode | POM |
| Source | BELGIUM |
| Agent | TRANS ARABIA DRUG STORE |
| Retail Price | 6330.00 AED |
Indications
Cyanokit Infusion is used for:
Vitamin B12 deficiency, Cyanide poisoning
Adult Dose
Adult
Intramuscular
30 mcg daily for 5 to 10 days followed by 100 to 200 mcg monthly.
Child Dose
Children
Intramuscular
1 to 5 mg over a period of 2 or more weeks in doses of 100 mcg, then 30 to 50 mcg every 4 weeks for maintenance.
Renal Dose
Administration
Contra Indications
Hypersensitivity to any component of this medication.
Precautions
The validity of diagnostic vitamin B12 or folic acid blood assays could be compromised by medications, and this should be considered before relying on such tests for therapy.
Vitamin B12 is not a substitute for folic acid and since it might improve folic acid deficient megaloblastic anemia, indiscriminate use of vitamin B12 could mask the true diagnosis.
Hypokalemia and thrombocytosis could occur upon conversion of severe megaloblastic to normal erythropoiesis with B12 therapy. Therefore, serum potassium levels and the platelet count should be monitored carefully during therapy.
Vitamin B12 deficiency may suppress the signs of polycythemia vera. Treatment with vitamin B12 may unmask this condition.
Pregnancy-Lactation
Pregnancy
Available data from cases reported in published literature and postmarketing surveillance in pregnant women are insufficient to identify a drug-associated risk for major birth defects, miscarriage, or adverse maternal and fetal outcomes
There are risks to pregnant woman and fetus associated with untreated cyanide poisoning
Cyanide readily crosses the placenta; cyanide poisoning is a medical emergency in pregnancy which can be fatal for pregnant woman and fetus if left untreated; life-sustaining therapy should not be withheld due to pregnancy
Lactation
Breastfeeding not recommended during treatment; there are no data to determine whenbreastfeeding may be safely restarted following administration of drug; hydroxocobalamin and Vitamin B12 (which is formed when hydroxocobalamin combines with cyanide) are present in human milk; there are no data on effects of hydroxocobalamin on breastfed infant or effects on milk production
Interactions
history of interaction with ARI Sodium Iodide (I123) 1-12 MBq (sodium iodide i-123)
ARI Sodium Iodide (I123) 100-750 MBq (sodium iodide i-123)
arsenic trioxide
Chloracol (chloramphenicol)
chloramphenicol
Chloromycetin (chloramphenicol)
Chloromycetin Sodium Succinate (chloramphenicol)
Hicon (sodium iodide-i-131)
Iodotope (sodium iodide-i-131)
sodium iodide i-123
sodium iodide-i-131
Trisenox (arsenic trioxide)
Adverse Effects
Side effects of Hydroxocobalamin :
Mild transient diarrhea, itching, transitory exanthema, feeling of swelling of entire body, and anaphylaxis.
A few patients may experience pain after injection of hydroxocobalamin.
Mechanism of Action
Vitamin B12 with hydroxyl group complexed to cobalt which can be displaced by cyanide resulting in cyanocobalamin that is renally excreted.
Note
Cyanokit 5g Infusion manufactured by SERB SA. Its generic name is Hydroxocobalamin. Cyanokit is availble in United Arab Emirates.
Farmaco UAE drug index information on Cyanokit Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.