Di-Gel (Lemon/Orange) Liquid (Oral)
Aluminium Hydroxide + Magnesium Hydroxide + Simethicon
Combination
PLOUGH INC.
| Pack size | 6 oz |
|---|---|
| Dispensing mode | P |
| Source | USA |
| Agent | GULF DRUG EST. |
| Retail Price | 9.50 AED |
Available as:
Indications
Di-Gel (Lemon/Orange) Liquid (Oral) is used for:
Dyspepsia, Flatulence
Adult Dose
Adult: Dyspepsia, Abdominal Bloating
10-20 mL PO q4-6hr taken 1 hour before or 3 hours after meals, OR
Chew 2-4 tablets q4-6hr; not to exceed 12 tablets/24 hr
PO Antacid Up to 1 g/day.
Hyperphosphataemia in chronic renal failure Up to 10 g/day in divided doses w/ meals.
Child Dose
Renal Dose
Administration
Administration Should be taken on an empty stomach.
Contra Indications
Hypersensitivity to aluminium salts.
Precautions
Chronic renal impairment; CHF; oedema; cirrhosis and low Na diets; patients with recent GI haemorrhage. Administer 2-3 hrs before/after another medication to minimise drug interactions. Pregnancy and lactation.
Lactation: excretion in milk unknown
Pregnancy-Lactation
Pregnancy Category: C
Lactation: excretion in milk unknown
Interactions
Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.
Magnesium Hydroxide: Decreases absorption of tetracyclines and biphosphonates. Separate administration of these and other drugs by around 2 hr.
Simethicon: None well documented.
Adverse Effects
Side effects of Aluminium Hydroxide + Magnesium Hydroxide + Simethicon :
Aluminum hydroxide
Chalky taste, Constipation, Fecal impaction, Stomach cramps, Nausea, Vomiting, Rebound hyperacidity, Aluminum intoxication, Hypophosphatemia, Milk-alkali syndrome, Osteomalacia
Magnesium hydroxide
Diarrhea, Hypermagnesemia
Simethicone
Loose stools
Mechanism of Action
Aluminum hydroxide: Neutralizes stomach hydrocloride to form AlCl3 salt plus water; increases gastric pH.
Magnesium hydroxide: Promotes bowel evacuation by causing osmotic retention of fluid, which causes the colon to distend with increased peristaltic activity; forms magnesium chloride when reacts with hydrochloric acid.
Simethicone: Disperses and prevents gas pockets in the GI system by decreasing surface tension of gas bubles.
Note
Di-Gel (Lemon/Orange) Combination Liquid (Oral) manufactured by PLOUGH INC.. Its generic name is Aluminium Hydroxide + Magnesium Hydroxide + Simethicon. Di-Gel (Lemon/Orange) is availble in United Arab Emirates.
Farmaco UAE drug index information on Di-Gel (Lemon/Orange) Liquid (Oral) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.