Dicetel Tablets / Film-coated
Perindopril Erbumine
100mg
Abbott Laboratories S.A
| Pack size | 20's (10's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | ALPHAMED CO. (AUH) LTD. |
| Retail Price | 35.00 AED |
Available as:
Indications
Dicetel Tablets / Film-coated is used for:
Hypertension, IHD, Heart failure
Adult Dose
Oral
Adult
Hypertension
4-8 mg PO qDay or divided q12hr
Maximum: 16 mg/day PO divided q12hr
Stable Coronary Artery Disease (CAD)
4 mg PO qDay for 2 weeks, THEN increase as tolerated to 8 mg/day PO divided q12hr
Reduce risk of cardiovascular mortality or MI in patients with stable CAD
Heart Failure
2 mg PO qDay initially to maximum 8-16 mg PO qDay
Elderly: Initially, 2 mg once daily. Dose may be increased to max 8 mg
Child Dose
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
<15 2 mg on dialysis days.
15-30 2 mg on alternate days.
30-60 2 mg
Administration
Should be taken on an empty stomach. Take before meals.
Contra Indications
History of angioedema related to previous ACE inhibitor treatment. Pregnancy (2nd/3rd trimesters).
Precautions
History of airway surgery. Withdraw if there is significant increase in LFTs. Risk factors for hyperkalaemia; monitor potassium closely. Patients dependent on renin-angiotensin-aldosterone system; consider withdrawal in patients with progressive deterioration in renal function. Collagen vascular disease. Hypovolaemia; monitor BP with the 1st dose. Unilateral renal artery stenosis and pre-existing renal insufficiency; valvular aortic stenosis. Before, during, or immediately after anaesthesia. May impair ability to drive or operate machinery. Lactation.
Lactation: not known if distributed into breast milk; use caution
Pregnancy-Lactation
Pregnancy Category: D
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, drugs that act directly on the renin-angiotensin have been associated with fetal injury that includes hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death
Lactation: not known if distributed into breast milk; use caution
Interactions
May enhance hypotensive effect w/ diuretics. Additive hyperkalaemic effect w/ K supplements, K-sparing diuretics, and other drugs (e.g. ciclosporin, heparin, indometacin). May increase serum levels and toxicity of lithium. Antihypertensive effect may be reduced by aspirin or other NSAIDs. Coadministration w/ NSAIDs may also increase the risk of renal impairment. Increased risk of hypoglycaemia w/ antidiabetic agents. Rarely, nitritoid reactions occur w/ concomitant use of gold (sodium aurothiomalate).
Potentially Fatal: Increased risk of hypotension, hyperkalaemia and changes in renal function (including acute renal failure) w/ aliskiren in patients w/ diabetes or renal impairment.
Adverse Effects
Side effects of Perindopril Erbumine :
>10%
Headache (23%), Cough (12%)
1-10%
Dizziness (8%), Back pain (6%), Lower extremity pain (5%), Abnormal ECG (2%), Palpitation (1%), Depression (2%), Somnolence (1%), Menstrual disorder (1%), Edema (4%), ALT increased (2%), Sexual dysfunction (male 1%), Sleep disorder (3%), Chest pain (2%), Nausea/vomiting (2%), Flatulence (1%), Rash (2%), Hyperkalemia (1%), Tinnitus (2%)
Frequency Not Defined
Intestinal angioedema, Liver failure (rare), Leukopenia, Pruritus, Stroke, Syncope, Urinary retention, Vertigo, Amnesia
Angioedema, More frequent in black patients (0.1%), Angioedema of lips, More frequent in black patients (0.1%), Angioedema of throat, More frequent in black patients (0.1%)
Potentially Fatal: Anaphylactoid reactions, angioedema.
Mechanism of Action
Perindopril is an ACE inhibitor, which acts by inhibiting the conversion of angiotensin I to angiotensin II, reducing the activity of the sympathetic nervous system and inhibiting enzyme kininase, which is involved in the conversion of bradykinin and other substances.
Note
Dicetel 100mg Tablets / Film-coated manufactured by Abbott Laboratories S.A. Its generic name is Perindopril Erbumine. Dicetel is availble in United Arab Emirates.
Farmaco UAE drug index information on Dicetel Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.