Droperidol Aguettant Injection
Droperidol
1.25mg/ml
LABORATOIRE AGUETTANT
| Pack size | 1ml Glass Ampoule x 10 |
|---|---|
| Dispensing mode | CD |
| Source | FRANCE |
| Agent | PHARMALINK |
| Retail Price | 156.00 AED |
Available as:
Indications
Droperidol Aguettant Injection is used for:
Nausea, vomiting
Adult Dose
Intravenous
Treatment and prophylaxis of postoperative nausea and vomiting
Adult: 0.625-1.25 mg 30 min prior to anticipated end of surgery, repeat 6 hrly, as necessary.
Hepatic impairment: 0.625 mg 30 min prior to anticipated end of surgery, repeat 6 hrly, as necessary.
Prophylaxis of nausea and vomiting associated with postoperative patient controlled analgesia (PCA)
Adult: 15-50 mcg per mg of morphine. Max: 5 mg daily.
Child Dose
Intravenous
Treatment and prophylaxis of postoperative nausea and vomiting
Child: 2-18 yr 10-50 mcg/kg (Max: 1.25 mg) 30 min prior to anticipated end of surgery, repeat 6 hrly, as necessary.
Renal Dose
Renal impairment: 0.625 mg 30 min prior to anticipated end of surgery, repeat 6 hrly, as necessary.
Administration
IV/IM Administration
Administered IM or slow IV (2-5 min)
IV infusion has been used in high-risk pts
Contra Indications
Severe depression, Parkinson's disease, coma, phaeochromocytoma, hypokalaemia, hypomagnesaemia, bradycardia (<55 heartbeats/min), known or suspected QT prolongation (QTc >440 millisecond in male and >450 millisecond in female). Concomitant use w/ class IA/III antiarrhythmics, macrolides, fluoroquinolones, antihistamines, certain antipsychotics, antimalarials, cisapride, domperidone, methadone, pentamidine, metoclopramide and other neuroleptics.
Precautions
Patient w/ epilepsy, risk factors for cardiac arrhythmia (e.g. history of serious ventricular arrhythmia, 2nd- or 3rd-degree AV block, sinus node dysfunction, CHF, ischaemic heart disease and left ventricular hypertrophy), glaucoma, COPD, resp failure, prolactin-dependent tumours (e.g. breast cancer), risk factors for electrolyte imbalance, history of alcohol abuse. Renal and hepatic impairment. Elderly, childn. Pregnancy and lactation. Patient CounsellingThis drug may cause drowsiness, if affected, do not drive or operate machinery. Avoid exposure to direct sunlight.
Monitoring Parameters Perform ECG monitoring at baseline and continue for 2-3 hr after admin. Monitor vital signs, serum Mg and K, mental status, abnormal involuntary movement scale (AIMS). Observe for dystonia, extrapyramidal side effects and temp changes.
Pregnancy-Lactation
Pregnancy Category: C
Lactation: distributed into breast milk; avoid
Interactions
May induce electrolyte imbalance when used w/ K-wasting diuretics, laxatives and glucocorticoids. May potentiate the sedative effect of barbiturates, benzodiazepines, morphine derivatives. May cause orthostatic hypotension w/ antihypertensive agents. May inhibit the action of dopamine agonists (e.g. bromocriptine, lisuride, levodopa). Prolonged effects w/ CYP1A2 (e.g. ciprofloxacin) and CYP3A4 (e.g. ketoconazole) inhibitors.
Adverse Effects
Side effects of Droperidol :
>10%
Restlessness
Anxiety
Extrapyramidal Symptoms
Dystonic reactions
Pseudoparkinsonian signs and symptoms
Tardive dyskinesia
Seizure
Altered central temperature regulation
Sedation
Drowsiness
Prolonged QT interval (dose dependent)
Swelling of breasts
Weight gain
Constipation
1-10%
Hallucinations
Persistent tardive dyskinesia
Akathisia
Orthostatic hypotension
Tachycardia
ECG: abnormal T waves
Hypertension
Nausea
Vomiting
Dysuria
Mechanism of Action
Droperidol blocks dopamine in the chemoreceptor trigger zone in the area postrema. It produces mild α-adrenergic blockade, peripheral vasodilation and reduction of the pressor effect of epinephrine resulting in hypotension and decreased peripheral resistance. It may also reduce pulmonary artery pressure.
Note
Droperidol Aguettant 1.25mg/ml Injection manufactured by LABORATOIRE AGUETTANT. Its generic name is Droperidol. Droperidol Aguettant is availble in United Arab Emirates.
Farmaco UAE drug index information on Droperidol Aguettant Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.