Duodart Capsules (Hard Gelatin)
Dutasteride, Tamsulosin HCl
" 0.5mg, 0.4mg"
GLAXOSMITHKLINE GmbH & Co. KG.
| Pack size | 30's HDPE Bottle |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | AL ITTIHAD DRUG STORE |
| Retail Price | 143.00 AED |
Indications
Duodart Capsules (Hard Gelatin) is used for:
DUTASTERIDE
For the treatment of symptomatic benign prostatic hyperplasia (bph) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for surgery
TAMSULOSIN
Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream... Etc. )
For the treatment of symptomatic benign prostatic hyperplasia (bph) in men with an enlarged prostate gland to improve symptoms, and reduce the risk of acute urinary retention and the need for surgery
TAMSULOSIN
Used in the treatment of signs and symptoms of benign prostatic hyperplasia (reduction in urinary obstruction and relief of associated manifestations such as hesitancy, terminal dribbling of urine, interrupted or weak stream... Etc. )
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Dutasteride, Tamsulosin HCl :
Mechanism of Action
DUTASTERIDE
Dutasteride inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (dht), which is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to dht by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5 alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor
TAMSULOSIN
Tamsulosin is a selective antagonist at alpha-1a and alpha-1b-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1a, alpha-1b and alpha-1d; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1a subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men
Dutasteride inhibits the conversion of testosterone to 5 alpha-dihydrotestosterone (dht), which is the androgen primarily responsible for the initial development and subsequent enlargement of the prostate gland. Testosterone is converted to dht by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5 alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human androgen receptor
TAMSULOSIN
Tamsulosin is a selective antagonist at alpha-1a and alpha-1b-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1a, alpha-1b and alpha-1d; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1a subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate, and thus decreases urinary outflow resistance in men
Note
Duodart " 0.5mg, 0.4mg" Capsules (Hard Gelatin) manufactured by GLAXOSMITHKLINE GmbH & Co. KG.. Its generic name is Dutasteride, Tamsulosin HCl. Duodart is availble in United Arab Emirates.
Farmaco UAE drug index information on Duodart Capsules (Hard Gelatin) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.