Duotrav Eye Drops (Solution)
Timolol Maleate 0.5% + Travoprost 0.004% Eye prep
"40mcg, 5mg/ml"
ALCON-COUVREUR n.v.
| Pack size | 2.5ml Dropper Bottle |
|---|---|
| Dispensing mode | POM |
| Source | BELGIUM |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 90.00 AED |
Indications
Duotrav Eye Drops (Solution) is used for:
Open-angle glaucoma, Ocular hypertension
Adult Dose
Ophthalmic
Ocular hypertension, Open-angle glaucoma
Adult: Instill 1 drop in the conjunctival sac of the affected eye(s) once daily, given at the same time each day.
Child Dose
The efficacy and safety below the age of 18 years have not been established.
Renal Dose
Administration
Contra Indications
Reactive airway disease including existing or history of bronchial asthma; severe COPD; sinus bradycardia, sick sinus syndrome including sino-atrial block, 2nd- or 3rd-degree AV block (not controlled by pacemaker); overt cardiac failure, cardiogenic shock; severe allergic rhinitis, corneal dystrophies. Pregnancy.
Precautions
Patient w/ 1st degree heart block, severe peripheral circulatory disorders (e.g. severe forms of Raynaud's disease/syndrome), mild/moderate COPD, corneal disease, labile diabetes or those who are subject to spontaneous hypoglycaemia. Aphakic patients, pseudoaphakic patients w/ torn posterior lens capsule or anterior chamber lenses or to those at risk for cystoid macular oedema. Lactation.
Pregnancy-Lactation
Interactions
Potential additive effect w/ oral Ca channel blockers, β-adrenergic blockers, antiarrhythmics, digitalis glycosides, parasympathomimetics, guanethidine. May potentiate hypertensive reaction to sudden withdrawal of clonidine. May potentiate systemic β-blockade w/ CYP2D6 inhibitors (e.g. quinidine, paroxetine). Risk of mydriasis w/ epinephrine. May increase the hypoglycaemic effect of antidiabetic agents.
Adverse Effects
Side effects of Timolol Maleate 0.5% + Travoprost 0.004% Eye prep :
The most frequently reported treatment-related undesirable effect was ocular hyperaemia. Other common side-effects may be keratitis, anterior chamber flare, eye pain, photophobia, eye swelling, conjunctival haemorrhage, corneal staining, ocular discomfort, visual acuity reduced, visual disturbance, blurred vision etc.
Mechanism of Action
Exact mechanism of ocular hypotensive effect is unclear, but it is thought to be related to reduction of aqueous humour formation. beta-blockade also causes lowering of BP.
Travoprost, a prodrug and synthetic analogue of dinoprost (prostaglandin F2alpha), reduces intraocular pressure by increasing uveoscleral outflow of aqueous humour.
Note
Duotrav "40mcg, 5mg/ml" Eye Drops (Solution) manufactured by ALCON-COUVREUR n.v.. Its generic name is Timolol Maleate 0.5% + Travoprost 0.004% Eye prep. Duotrav is availble in United Arab Emirates.
Farmaco UAE drug index information on Duotrav Eye Drops (Solution) is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.