ETIMICOL Tablet

Ezetimibe
10mg
Aurobindo Pharma FZ LLC
Pack size 30's (10’s Blister x 3)
Dispensing mode POM
Source UAE
AgentAL ITTIHAD DRUG STORE
Retail Price 80.00 AED

Indications

ETIMICOL Tablet is used for: Hyperlipidaemias, Homozygous familial sitosterolaemia, Hypercholesterolaemia

Adult Dose

Oral Hyperlipidaemias; Homozygous familial sitosterolaemia Adult: 10 mg once daily. Hepatic impairment Mild (Child-Pugh class A): Dose adjustment not necessary Moderate to severe (Child-Pugh class B or C): Not recommended

Child Dose

Child: >10 yr: 10 mg once daily.

Renal Dose

Renal impairment Monotherapy: No dosage adjustment required Moderate to severe: Renal impairment is a risk factor for statin-associated myopathy; caution when coadministered with doses of simvastatin exceeding 20 mg

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity; moderate to severe liver disease or unexplained serum transaminase elevation. Children <10 yr, lactation.

Precautions

Renal or mild hepatic impairment. Monitor LFTs. Immediately discontinue ezetimibe and any HMG-CoA reductase inhibitor or fibrate if myopathy is diagnosed or suspected. Exclude or treat secondary causes of dyslipidaemia prior to initiating therapy. Lactation: Excretion in milk unknown; use with caution

Pregnancy-Lactation

Pregnancy category: C Lactation: Excretion in milk unknown; use with caution

Interactions

Reduced absorption w/ colestyramine. Increased plasma concentrations w/ ciclosporin. Concomitant use w/ oral anticoagulants may result in increased INR.

Adverse Effects

Side effects of Ezetimibe : 1-10% Diarrhea (4%), Upper respiratory tract symptoms (2-4%), Cough (2-4%), Pain in extremity (3%), Sinusitis (3%), Arthralgia (2-3%), Fatigue (2%), Influenza (2%), Increased liver transaminases (with HMG-CoA reductase inhibitors; >3 x ULN; 1%)

Mechanism of Action

Ezetimibe localises at the brush border of the small intestine where it inhibits the absorption of cholesterol, thus decreasing its delivery to the liver. This results in decrease in cholesterol stores within the liver and an increase in cholesterol clearance from the blood.

Note

ETIMICOL 10mg Tablet manufactured by Aurobindo Pharma FZ LLC. Its generic name is Ezetimibe. ETIMICOL is availble in United Arab Emirates. Farmaco UAE drug index information on ETIMICOL Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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