Evista Tablets / Film-coated
Raloxifene Hydrochloride
60mg
LILLY SA
| Pack size | 28's (14's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | SPAIN |
| Agent | PHARMATRADE |
| Retail Price | 142.00 AED |
Indications
Evista Tablets / Film-coated is used for:
Post-menopausal osteoporosis, Malignant gastrointestinal stromal tumours, Prevention & risk reduction of invasive breast cancer
Adult Dose
Oral
Prophylaxis of postmenopausal osteoporosis; Osteoporosis in postmenopausal women
Adult: 60 mg once daily.
Breast Cancer
Prevention; risk reduction of invasive breast cancer in postmenopausal women at high risk for invasive breast cancer
60 mg PO qDay for 5 years
Hepatic impairment: Contraindicated.
Child Dose
Renal Dose
Renal impairment: Severe: Contraindicated.
Administration
May be taken with or without food.
Contra Indications
Active or history of venous thromboembolic events including DVT, pulmonary embolism, retinal vein thrombosis. Unexplained uterine bleeding. Patients w/ signs/symptoms of endometrial cancer. Hepatic (including cholestasis) and severe renal impairment. Pregnancy, women who may become pregnant, and lactation.
Precautions
Women w/ risk factors for venous thromboembolism including CHF or active malignancy, risk factors for stroke (e.g. TIA, AF), history of oestrogen-induced hypertriglyceridaemia. Moderate renal impairment. Monitoring Parameters Monitor serum triglyceride concentration.
Lactation: Excretion in milk unknown; contraindicated
Pregnancy-Lactation
Pregnancy Category: X
Lactation: Excretion in milk unknown; contraindicated
Interactions
Cholestyramine reduces the absorption of raloxifene. Raloxifene with warfarin may reduce the prothrombin response and time. Caution when used in hghly protein-bound drugs such as diazepam, lidocaine and diazoxide.
Adverse Effects
Side effects of Raloxifene Hydrochloride :
>10%
Hot flashes (8-29%), Flu syndrome (14-15%), Cramps/muscle spasm (6-12%), Arthralgia (11-16%), Infection (11%)
1-10%
Insomnia (6%), Vomiting (5%), Sinusitis (10%), Venous thromboembolism (1-2% ), Bronchitis (10%), Pharyngitis (8%), Breast pain (4%), Gastroenteritis (<3%), Diaphoresis (3%)
Frequency Not Defined
Deep vein thrombosis, Cerebrovascular accident, Thrombosis of retinal vein (rare), Pulmonary embolism, Decreased fibrinogen
Mechanism of Action
Raloxifene is a selective oestrogen receptor modulator that has both selective agonist or antagonist activities on oestrogen receptors. It acts as an agonist on bone by preventing bone loss and partially on cholesterol metabolism by decreasing total and LDL cholesterol levels but antagonises oestrogen effects leading to development of breast and uterine cancer.
Note
Evista 60mg Tablets / Film-coated manufactured by LILLY SA. Its generic name is Raloxifene Hydrochloride. Evista is availble in United Arab Emirates.
Farmaco UAE drug index information on Evista Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.