Fansidar Tablets
Pyrimethamine, Sulfadoxine
"25mg, 500mg"
F. Hoffmann-La Roche Ltd.
| Pack size | 500's (2 Boxes of 10's Strip x 25) |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | IBN KHALDOON DRUG STORE |
| Retail Price | 609.50 AED |
Indications
Fansidar Tablets is used for:
SULFADOXINE
Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected
PYRIMETHAMINE
For the treatment of toxoplasmosis and acute malaria; for the prevention of malaria in areas non-resistant to pyrimethamine
Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected
PYRIMETHAMINE
For the treatment of toxoplasmosis and acute malaria; for the prevention of malaria in areas non-resistant to pyrimethamine
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Pyrimethamine, Sulfadoxine :
Mechanism of Action
SULFADOXINE
Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine targets plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (paba) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid
PYRIMETHAMINE
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for dna synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver
Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine targets plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (paba) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid
PYRIMETHAMINE
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for dna synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver
Note
Fansidar "25mg, 500mg" Tablets manufactured by F. Hoffmann-La Roche Ltd.. Its generic name is Pyrimethamine, Sulfadoxine. Fansidar is availble in United Arab Emirates.
Farmaco UAE drug index information on Fansidar Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.