Fansidar Tablets

Pyrimethamine, Sulfadoxine
"25mg, 500mg"
F. Hoffmann-La Roche Ltd.
Pack size 500's (2 Boxes of 10's Strip x 25)
Dispensing mode POM
Source SWITZERLAND
AgentIBN KHALDOON DRUG STORE
Retail Price 609.50 AED

Indications

Fansidar Tablets is used for: SULFADOXINE
Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxine and pyrimethamine is indicated for the treatment of plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected
PYRIMETHAMINE
For the treatment of toxoplasmosis and acute malaria; for the prevention of malaria in areas non-resistant to pyrimethamine

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Pyrimethamine, Sulfadoxine :

Mechanism of Action

SULFADOXINE
Sulfadoxine is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxine targets plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (paba) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid
PYRIMETHAMINE
Pyrimethamine inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for dna synthesis and cell multiplication. This leads to failure of nuclear division at the time of schizont formation in erythrocytes and liver

Note

Fansidar "25mg, 500mg" Tablets manufactured by F. Hoffmann-La Roche Ltd.. Its generic name is Pyrimethamine, Sulfadoxine. Fansidar is availble in United Arab Emirates. Farmaco UAE drug index information on Fansidar Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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