Flexiban Tablets
Cyclobenzaprine Hydrochloride
10mg
Algorithm S.A.L.
| Pack size | 30's |
|---|---|
| Dispensing mode | SCD |
| Source | LEBANON |
| Agent | CITY MEDICAL STORE |
| Retail Price | 30.00 AED |
Indications
Flexiban Tablets is used for:
Fibromyalgia, Muscle spasm
Adult Dose
Oral
Painful muscle spasm associated with musculoskeletal conditions
Adult: 5 mg tid, may increase to 10 mg tid if needed. Treatment should not last more than 2-3 wk. Max: 60 mg.
Elderly: Initiate with 5 mg with less frequent dosing.
Max Dosage: 60 mg.
Hepatic impairment: MIld: Start with 5 mg dose with less frequent dosing. Moderate to severe: Not recommended.
Child Dose
Muscle Spasm
Oral
<15 years: Safety and efficacy not established
>15 years: 5 mg PO q8hr; may increase dose to 10 mg PO q8hr PRN
Renal Dose
Administration
Contra Indications
Recent MI, arrhythmias, severe liver disease.
Precautions
Cardiac disease, history of epilepsy, hepatic impairment, hyperthyroidism, pheochromocytoma, history of mania, psychoses, close-angle glaucoma, history of urinary retention, concurrent electroconvulsive therapy, diabetes. Pregnancy and lactation; elderly, child. Unsafe for use in patients with porphyria. Avoid abrupt withdrawal. May cause drowsiness; do not drive or operate machinery. Treatment for more than 2-3 wk is not recommended.
Lactation: Excretion in milk unknown; use with caution
Pregnancy-Lactation
Pregnancy
Available data from case reports with use in pregnancy have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes
Lactation
There are no data on presence of drug in either human or animal milk, the effects on a breastfed infant, or effects on milk production; developmental and health benefits of breastfeeding should be considered along with mother’s clinical need for therapy and any potential adverse effects on breastfed child from therapy or from underlying maternal condition.
Interactions
Plasma concentration may be increased with the use of cimetidine, diltiazem, disulfiram, methylphenidate, ritonavir, and verapamil. Side-effects are increased by adrenaline, amiodarone, general anesthetics, SSRIs, antihistamines, antimuscarinics, antipsychotics, anxiolytics and hypnotics, clozapine, disopyramide, diuretics, flecainide, MAOIs, moclobemide, moxifloxacin, nefopam, nicorandil, noradrenaline, phenothiazine, pimozide, procainamide, propafenone, quinidine, selegiline, sibutramine, sotalol, terfenadine, thioridazine, and tramadol.
Effects of adrenergic neurone blockers, clonidine, barbiturates, nitrates, and primidone are reduced while effects of baclofen, opioid analgesics, and thyroid hormones are enhanced with concomitant use of cyclobenzaprine. Carbamazepine and rifampicin may increase metabolism of cyclobenzaprine. Effects may be antagonized by oestrogens. Avoid use with brimonidine, entacapone, artemether with lumefantrine, or sibutramine. CNS effects may be enhanced by other CNS depressants.
Adverse Effects
Side effects of Cyclobenzaprine Hydrochloride :
>10%
Drowsiness (up to 39% immediate-release), Dry mouth (21-32%), Dizziness (3-11%)
1-10%
Pharyngitis (1-3%), Headache (1-5%), Fatigue (6%), Palpitations (6%), Bad taste in mouth (1-6%), Indigestion (4%), Blurred vision (3%), Constipation (1-3%), Asthenia (1-3%), Confusion (1-3%), Nausea (1-3%), Nervousness (1-3%)
<1%
Arrhythmia, Hypotension, Palpitation, Syncope, Tachycardia, Vasodilation, Cardiac dysrhythmia (rare), Cholestasis (rare), Hepatitis, Jaundice, Anaphylaxis (rare), Immune hypersensitivity reaction
Mechanism of Action
Cyclobenzaprine, a centrally-acting skeletal muscle relaxant, is structurally related to tricyclic antidepressants, thus they share similar properties. It acts on the brain stem, decreasing tonic-somatic motor activities influencing both the ? and ? motor systems. It is used as an adjunct in the symptomatic treatment of painful muscle spasms associated with musculoskeletal conditions.
Note
Flexiban 10mg Tablets manufactured by Algorithm S.A.L.. Its generic name is Cyclobenzaprine Hydrochloride. Flexiban is availble in United Arab Emirates.
Farmaco UAE drug index information on Flexiban Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.