FLUMED DM ADULT Syrup

Chlorpheniramine maleate, Pseudoephedrine HCl, Dextromethorphan HBr
"2mg, 30mg, 10mg/5ml"
Riyadh Pharma (Medical and Cosmetic Products Company Ltd.)
Pack size 100ml Glass Bottle
Dispensing mode POM-R (Dispense maximum for one month)
Source SAUDI ARABIA
AgentModern Pharmaceutical Co.
Retail Price 7.00 AED

Indications

FLUMED DM ADULT Syrup is used for: PHENIRAMINE
Pheniramine is an antihistamine used to treat allergic conditions such as hay fever or urticaria
PSEUDOEPHEDRINE
For the treatment of nasal congestion, sinus congestion, eustachian tube congestion, and vasomotor rhinitis, and as an adjunct to other agents in the optimum treatment of allergic rhinitis, croup, sinusitis, otitis media, and tracheobronchitis. Also used as first-line therapy of priapism
DEXTROMETHORPHAN
For treatment and relief of dry cough

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Chlorpheniramine maleate, Pseudoephedrine HCl, Dextromethorphan HBr :

Mechanism of Action

PHENIRAMINE
Antihistamines such as pheniramine appear to compete with histamine for histamine h1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of h1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for h1-receptors
PSEUDOEPHEDRINE
Pseudoephedrine acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, pseudoephedrine produces vasoconstriction. Pseudoephedrine relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, pseudoephedrine releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors
DEXTROMETHORPHAN
Dextromethorphan is an opioid-like drug that binds to and acts as antagonist to the nmda glutamatergic receptor, it is an agonist to the opioid sigma 1 and sigma 2 receptors, it is also an alpha3/beta4 nicotinic receptor antagonist and targets the serotonin reuptake pump. Dextromethorphan is rapidly absorbed from the gastrointestinal tract, where it enters the bloodstream and crosses the blood-brain barrier. The first-pass through the hepatic portal vein results in some of the drug being metabolized into an active metabolite of dextromethorphan, dextrorphan, the 3-hydroxy derivative of dextromethorphan

Note

FLUMED DM ADULT "2mg, 30mg, 10mg/5ml" Syrup manufactured by Riyadh Pharma (Medical and Cosmetic Products Company Ltd.). Its generic name is Chlorpheniramine maleate, Pseudoephedrine HCl, Dextromethorphan HBr. FLUMED DM ADULT is availble in United Arab Emirates. Farmaco UAE drug index information on FLUMED DM ADULT Syrup is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Chlorpheniramine maleate, Pseudoephedrine HCl, Dextromethorphan HBr :