Fortace Tablet
Ramipril
2.5mg
Pharmax Pharmaceuticals FZ LLC
| Pack size | 30's(10's Blister x 3) |
|---|---|
| Dispensing mode | POM |
| Source | UAE |
| Agent | AL ITTIHAD DRUG STORE |
| Retail Price | 42.00 AED |
Available as:
Indications
Fortace Tablet is used for:
Congestive heart failure, MI, HTN, CV events, Stroke
Adult Dose
Oral
Hypertension, Diabetic Nephropathy
Adult: Hypertension
Initial (not on diuretic): 2.5 mg once daily at bedtime.
Initial (with diuretic): 1.25 mg once daily at bedtime.
Maintenance: 2.5-5 mg/day as a single dose, Max: 10 mg/day.
Congestive Heart failure
Adult: Initially, 1.25 mg once daily. Max: 10 mg daily. Doses >2.5 mg may be given in 2 divided doses.
Max Dosage: 10 mg daily in 1-2 divided doses.
Post myocardial infarction
Adult: Initially, 2.5 mg bid, may increase to 5 mg bid after 2 days. Start treatment: 3-10 days after infarction. Maintenance: 2.5-5 mg bid.
Prophylaxis of cardiovascular events in high-risk patients, Stroke Prevention
Adult: Initially, 2.5 mg once daily, may increase to 5 mg once daily after 1 wk if tolerated. Maintenance: 10 mg once daily after a further 3 wk.
Hepatic impairment: Max: 2.5 mg/day.
Child Dose
Safety and efficacy not established
Renal Dose
Renal impairment:
CrCl (ml/min) Dosage Recommendation
10-30 Initially, 1.25 mg/day. Max: 5 mg/day.
30-60 Not necessary to adjust the initial dose. Max maintenance dose: 5 mg/day.
Administration
May be taken with or without food.
Contra Indications
Hypersensitivity, bilateral renal artery stenosis, or a single kidney with unilateral renal artery stenosis. Aortic stenosis or outflow tract obstruction. History of angioedema (hereditary, idiopathic or due to previous angioedema w/ ACE inhibitors). Pregnancy and lactation.
Precautions
Renal impairment, hypovolaemia, hyperkalaemia, valvular stenosis; before, during or immediately after anaesthesia. Severe resistant hypertension, elderly, peripheral vascular disease or generalised atherosclerosis. Patient Counselling Inform patients to refrain from activities involving mental alertness and physical coordination after drug intake. Monitoring Parameters Correct volume and/or salt depletion prior to treatment. Monitor BP, serum creatinine and K levels. Monitor renal function during the 1st few wk of treatment and periodically thereafter.
Lactation: Possibly excreted in breast milk; nursing not recommended
Pregnancy-Lactation
Pregnancy category: D
Discontinue as soon as pregnancy detected; during the second and third trimesters of pregnancy, therapy can result in fetal injury (eg, hypotension, neonatal skull hypoplasia, anuria, reversible and irreversible renal failure) and death
Lactation: Possibly excreted in breast milk; nursing not recommended
Interactions
May enhance hypotensive effect w/ diuretics and other antihypertensives. May increase risk of renal function deterioration w/ NSAIDs. May increase serum levels and toxicity of lithum. May increase hyperkalaemic effect w/ K-sparing diuretics and supplements.
Potentially Fatal: Concomitant use w/ aliskiren aliskiren may increase the risk of hyperkalaemia, hypotension and nephrotoxicity in patients w/ diabetes or renal impairment
Adverse Effects
Side effects of Ramipril :
>10%
Cough (7-8%), Hypotension (2-11%)
1-10%
Headache (1-5%), Angina pectoris (3%), Dizziness (2-4%), Nausea (2%), Vomiting (2%), Postural hypotension (2%), Syncope (2%), Vertigo (2%), Abnormal kidney function (1%), Diarrhea (1%)
<1%
Angioedema (0.3%)
Potentially Fatal: Severe hypotension and renal failure, angioedema.
Mechanism of Action
Ramipril, a prodrug of ramiprilat, competitively inhibits ACE from converting angiotensin I to angiotensin II (a potent vasoconstrictor) resulting in increased plasma renin activity and reduced aldosterone (a hormone that causes water and Na retention) secretion. This promotes vasodilation thus producing a hypotensive effect and a beneficial effect in CHF.
Note
Fortace 2.5mg Tablet manufactured by Pharmax Pharmaceuticals FZ LLC. Its generic name is Ramipril. Fortace is availble in United Arab Emirates.
Farmaco UAE drug index information on Fortace Tablet is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.