FOSAVANCE Tablets

Alendronic Acid + Vitamin D3
"70mg, 5600 IU"
Merck Sharp & Dohme B.V.
Pack size 4's Blister
Dispensing mode POM
Source NETHERLANDS
AgentCITY MEDICAL STORE
Retail Price 199.50 AED

Indications

FOSAVANCE Tablets is used for: Osteopetrosis, postmenopausal osteoporosis, Paget's disease of bone

Adult Dose

Treatment of osteoporosis in postmenopausal women: One tablet once weekly. Treatment to increase bonemass in men with osteoporosis: One tablet once weekly. Hepatic Impairment No dosage adjustment needed.

Child Dose

Renal Dose

Dosing in elderly and renal insufficiency: No dosage adjustment is necessary for the elderly or for patients with mild-to-moderate renal insufficiency (creatinine clearance 35 to 60 mL/min). CrCl (ml/min) <35 Not recommended.

Administration

Contra Indications

Hypocalcaemia; oesophageal abnormalities and factors which delay oesophageal emptying; severe renal impairment; hypersensitivity; inability to stand or sit upright for <30 min. Pregnancy, lactation.

Precautions

Upper GI disorders (discontinue if symptoms worsen); history of ulcers, active GI bleeding. Correct vitamin D and calcium deficiency before starting therapy. To be taken half an hr before breakfast and remain upright for at least 30 minutes after admin. Not recommended for use in patients with CrCl <35 ml/min.

Pregnancy-Lactation

Alendronic Acid Pregnancy Available data on use in pregnant women insufficient to inform a drug-associated risk of adverse maternal or fetal outcomes; discontinue when pregnancy recognized. Lactation Not known whether drug present in human breast mild, affects milk production or has effects on infants Consider developmental and health benefits of breastfeeding along with mother’s clinical need for therapy and any potential effects on breastfed child from drug or underlying maternal condition Vitamin D3 Pregnancy There are no adequate and well-controlled studies in pregnant women Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus Animal studies Calcifediol has been shown to be teratogenic in rabbits when given in doses 8-16 times the human dose of 60 mcg/day, based on body surface area Lactation Limited data suggest calcifediol is poorly excreted in human milk; caution if administered to a breastfeeding female

Interactions

Concomitant iron, calcium supplements and antacids hinder alendronate absorption. Concomitant aspirin or NSAIDs may increase the incidence of adverse GI effects.

Adverse Effects

Side effects of Alendronic Acid + Vitamin D3 : The most common side-effect is digestive reactions. These reactions include irritation, inflammation, or ulcers of the esophagus, which may sometimes bleed. This may occur especially if patients do not drink a full glass of water or if they lie down in less than 30 minutes or before their first food of the day. Less common side-effects are nausea, vomiting, a full or bloated feeling in the stomach, constipation, diarrhea, black or bloody stools, gas, headache, a changed sense of taste, and bone, muscle, or joint pain.

Mechanism of Action

Alendronic acid reduces bone resorption by inhibiting the action of osteoclasts.

Note

FOSAVANCE "70mg, 5600 IU" Tablets manufactured by Merck Sharp & Dohme B.V.. Its generic name is Alendronic Acid + Vitamin D3. FOSAVANCE is availble in United Arab Emirates. Farmaco UAE drug index information on FOSAVANCE Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Alendronic Acid + Vitamin D3 :

Tablets
Bonyl "70mg, 2800 IU (56mg)"
ABDI IBRAHIM ILAC SANAYI VE TICARET ANONIM SIRKETI
Tablets
Bonyl Plus "70mg, 5600 IU (56mg)"
ABDI IBRAHIM ILAC SANAYI VE TICARET ANONIM SIRKETI
Tablet
"ACLONIA 70mg/2,800 IU" "70 mg/2,800 IU"
PHARMATHEN SA[Pallini
Tablet
"ACLONIA 70mg/5,600 IU" "70 mg/5,600 IU"
PHARMATHEN SA[Pallini
Tablets
FOSAVANCE "70mg, 2800 IU (70mcg)"
Merck Sharp & Dohme Limited