Froben Tablets

Flurbiprofen
50mg
Boots Co PLC
Pack size 100's
Dispensing mode POM
Source UK
AgentAL BAKER TRADING EST.
Retail Price 48.50 AED

Indications

Froben Tablets is used for: Dysmenorrhoea, Sore throat, Ocular inflammation, Pain and inflammation associated w/ musculoskeletal and joint disorders, Prophylaxis of miosis during ocular surgery

Adult Dose

Oral Pain and inflammation Adult: 150-200 mg daily in divided doses, increased to 300 mg daily in acute or severe conditions if necessary. Dysmenorrhoea Adult: Initially, 100 mg followed by 50-100 mg 4-6 hrly. Max: 300 mg daily. Rheumatoid Arthritis, Osteoarthritis 200-300 mg/day divided q6-12hr PO, not to exceed 100 mg/dose or 300 mg/day

Child Dose

<12 years: Not recommended

Renal Dose

Renal Impairment Severe Impairment: Not recommended

Administration

Should be taken with food.

Contra Indications

Peptic ulcer, GI haemorrhage, asthma, bronchospasm, rhinitis, angioedema, hypersensitivity; aspirin intolerance; pregnancy (3rd trimester); lactation.

Precautions

Patients w/ known CV disease or risk factors for CV disease, fluid retention. Hepatic and renal impairment. Lactation. Lactation: excreted in breast milk; not recommended

Pregnancy-Lactation

Pregnancy Category: C; avoid in late pregnancy Lactation: excreted in breast milk; not recommended

Interactions

Reduced antihypertensive effect of ACE inhibitors, angiotensin II receptor antagonists and ?-blockers. Slight reduction in blood glucose concentration in patients w/ DM receiving certain antidiabetic agents (e.g. glyburide, metformin). Reduced diuretic effect of furosemide and thiazides. May increase toxicity of lithium and methotrexate. May increase risk of bleeding w/ antiplatelets, anticoagulants, SSRIs, corticosteroids.

Adverse Effects

Side effects of Flurbiprofen : Oedema, abdominal pain, constipation, diarrhoea, dyspepsia/heartburn, liver enzyme elevations, flatulence, nausea, vomiting, wt change, headache, nervousness, CNS stimulation (e.g. anxiety), CNS inhibition (e.g. somnolence), rhinitis, vision changes, dizziness/vertigo, tinnitus, signs and symptoms of UTI, rash. Ocular hyperaemia, eye irritation, fibrosis, miosis, mydriasis. Potentially Fatal: GI bleeding, ulceration and perforation, jaundice, fulminant hepatitis, liver necrosis, hepatic failure.

Mechanism of Action

Flurbiprofen inhibits prostaglandin synthesis by decreasing the activity of cyclooxygenase resulting in reduced prostaglandin levels. It is also a potent inhibitor of platelet aggregation.

Note

Froben 50mg Tablets manufactured by Boots Co PLC. Its generic name is Flurbiprofen. Froben is availble in United Arab Emirates. Farmaco UAE drug index information on Froben Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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