Gentam Injection
Gentamicin
10mg/ml
SPIMACO (Al Qassim Pharmaceutical Plant)
| Pack size | 2ml Ampoule x 5 |
|---|---|
| Dispensing mode | POM |
| Source | SAUDI ARABIA |
| Agent | CITY MEDICAL STORE |
| Retail Price | 26.00 AED |
Available as:
Indications
Gentam Injection is used for:
Pneumonia, Cystic fibrosis, Meningitis, Peritonitis, Endocarditis, Susceptible infections, Septicaemia, Pelvic inflammatory disease, Endometritis, Biliary tract infections, Granuloma inguinale, Listeriosis, Gastroenteritis, Plague, Cat scratch disease, Brucellosis, Otitis externa, Surgical infections, Skin infections.
Adult Dose
Parenteral
Susceptible Infections
Adult: 3-5 mg/kg 8 hrly for 7-10 days, by IM or slow IV inj over 2-3 min or IV infusion over no more than 20-30 min.
Surgical Infection
Prophylaxis
Oral/pharyngeal: 1.5 mg/kg IV PLUS clindamycin 600-900 mg IV
Ruptured viscus: 1.5 mg/kg IV q8hr PLUS clindamycin 600 mg IV q6hr
Endocarditis
Prophylaxis
GI, GU procedure: 1.5 mg/kg IV/IM <30 minutes before procedure PLUS ampicillin or vancomycin
Cystic Fibrosis
7.5-10.5 mg/kg/day IV/IM divided q8hr
Pelvic Inflammatory Disease
Loading dose: 2 mg/kg IV or IM
Maintenance dose: 1.5 mg/kg IV or IM q8hr
Child Dose
Pediatric
IV, IM 3–7.5 mg/kg/day (cystic fibrosis 7–10); q8h
Up to 2 weeks: 3 mg/kg/every 12 hours
2 weeks to 12 years: 2 mg/kg/every 8 hours
Renal Dose
Renal impairment
CrCl >90 mL/min and <60 years: q8hr
CrCl 60-90 mL/min or ?60 years: q12hr
CrCl 25-60 mL/min: q24hr
CrCl 10-25 mL/min: q48hr
CrCl <10 mL/min: q72hr
Following dialysis in ESRD
Administration
IV Preparation
Dilute single dose in 50-200 mL NS or D5W
IV Administration
Infuse over 30 min-2 hr
After infusion, flush line with NS or D5W
Contra Indications
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.
Precautions
History of hypersensitivity to aminoglycoside; pregnancy; hepatic impairment, perforated ear drum.
Lactation: Enters breast milk; use with caution (AAP Committee states "compatible with nursing")
Pregnancy-Lactation
Pregnancy category: D
Lactation: Enters breast milk; use with caution (AAP Committee states "compatible with nursing")
Interactions
Synergistic with ampicillin, benzylpenicillin and other beta-lactam antibiotics. Increased risk of severe respiratory depression when used concurrently with anaesthetics or opioids. May reduce renal clearance of zalcitabine and induce hypocalcaemia when used with biphosphonates. Not to be used with agalsidase alfa or beta as it may inhibit alpha-galactosidase activity.
Potentially Fatal: Increased incidence of ototoxicity when combined with ethacrynic acid and furosemide. Cephalosporins, ciclosporin, cisplatin, vancomycin, hydrocortisone and indometacin potentiate nephrotoxicity. Potentiates neuromuscular blocking agents.
Adverse Effects
Side effects of Gentamicin :
>10%
Neurotoxicity (vertigo, ataxia), Gait instability, Ototoxicity (auditory, vestibular), Nephrotoxicity (decreased CrCl), Nephrotoxicity if trough >2 mg/L
1-10%
Edema, Rash, Reddening of skin, Itching
<1%
Drowsiness, Headache, Pseudomotor cerebri, Photosensitivity, Allergic reaction, Erythema, Anorexia, Nausea/vomiting, Weight loss, Increased salivation, Enterocolitis, Granulocytopenia, Agranulocytosis, Thrombocytopenia, Elevated LFT
Burning, Stinging, Tremors, Muscle cramps, Weakness, Dyspnea
Potentially Fatal: Nephrotoxicity, ototoxicity and neuromuscular blockade (may unmask or aggravate myasthaenia gravis).
Mechanism of Action
Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective.
Note
Gentam 10mg/ml Injection manufactured by SPIMACO (Al Qassim Pharmaceutical Plant). Its generic name is Gentamicin. Gentam is availble in United Arab Emirates.
Farmaco UAE drug index information on Gentam Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.