GONAL-F 450 IU Injection
Follitropin Alfa
33.34mcg/0.75ml
INDUSTRIA PHARMACEUTICA SERONO S.p.A.
| Pack size | 1 Prefilled Pen (0.75ml) + 7 Needles |
|---|---|
| Dispensing mode | POM |
| Source | ITALY |
| Agent | ARABIAN ETHICALS CO. |
| Retail Price | 612.00 AED |
Available as:
Indications
GONAL-F 450 IU Injection is used for:
Female infertility, Assisted reproductive technologies, Spermatogenesis induction
Adult Dose
Subcutaneous
Female infertility
Adult: Dose should be individualised. Recommended initial dose: 75 IU/day; may increase dose by up to 37.5 IU after 14 days; further increases of the same magnitude can be made, if needed, every 7 days. Max: 300 IU/day.
If response is appropriate, hCG (5,000 USP IU) is given 1 day after the last dose. Withhold hCG if serum estradiol is >2000 pg/ml, if the ovaries are abnormally enlarged or if abdominal pain occurs.
Generally, therapy should not exceed 35 days.
Assisted reproductive technologies
Adult: Initially, 150-225 IU/day for at least 4 days, to be started in the early follicular phase (cycle day 2 or 3), until follicular development is adequate.
Generally, therapy should not exceed 10 days.
In patients >35 yr old with suppressed endogenous gonadotropin levels, initiate at 225 IU/day. Continue until follicular development is adequate. Adjust dose based on ovarian response; adjust subsequent doses every 3-5 days by <75-150 IU additionally at each adjustment. Adequate follicular development usually occurs within 5-10 days of treatment. Usual max: 450 IU/day.
Once follicular development is adequate, administer hCG to induce final follicular maturation. Withhold hCG if ovaries are abnormally enlarged.
Spermatogenesis induction
Adult: Start treatment with hCG until serum testosterone is in normal range. Initiate with 150 IU 3 times/wk combined with continued chorionic gonadotrophin. Treatment should be given for at least 4 mths and may continue for >18 mth. Max: 300 IU 3 times wkly.
Child Dose
Renal Dose
Administration
Contra Indications
Hypersensitivity. Abnormal genital bleeding of undetermined origin, sex hormone sensitive malignancies of the reproductive tract and accessory organs, an organic intracranial lesion e.g. pituitary tumor, ovarian cysts or enlargement of undetermined origin, high levels of FSH indicating primary gonadal failure, uncontrolled thyroid or adrenal dysfunction, pregnancy, lactation.
Precautions
May result in multiple births. Ovarian hyperstimulation syndrome, serious pulmonary conditions and thromboembolic events may occur. Evaluate patients for hypothyroidism, adrenocortical deficiency, hyperprolactinaemia, pituitary and hypothalamic tumors before starting therapy.
Lactation: Excretion in milk unknown; not recommended
Pregnancy-Lactation
Pregnancy
Contraindicated
Lactation
Unknown if excreted in breast milk
Interactions
Other ovulation stimulating agents (eg hCG, clomiphene citrate) may potentiate the follicular response, concurrent use of GnRH agonist-induced pituitary desensitisation may increase the dosage of Gonal-f needed to elicit an adequate ovarian response.
Adverse Effects
Side effects of Follitropin Alfa :
Ovarian cysts, mild to severe Inj site reactions, headache, mild to moderate ovarian hyperstimulation syndrome (OHSS), abdominal pain, GI disturbances.
Rarely, severe OHSS, ovarian torsion, thromboembolism, mild systemic allergic reactions.
Mechanism of Action
Follitropin alfa is a human FSH preparation of recombinant DNA origin. It stimulates ovarian follicular growth in women who do not have primary ovarian failure and stimulates spermatogenesis in men with hypogonadotrophic hypogonadism.
Note
GONAL-F 450 IU 33.34mcg/0.75ml Injection manufactured by INDUSTRIA PHARMACEUTICA SERONO S.p.A.. Its generic name is Follitropin Alfa. GONAL-F 450 IU is availble in United Arab Emirates.
Farmaco UAE drug index information on GONAL-F 450 IU Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.