Harvoni Tablets / Film-coated

Ledipasvir, Sofosbuvir
"90mg, 400mg"
GILEAD SCIENCES INTERNATIONAL LTD.
Pack size 28's HDPE Bottle
Dispensing mode POM
Source UK
AgentModern Pharmaceutical Co.
Retail Price 90692.00 AED

Indications

Harvoni Tablets / Film-coated is used for: LEDIPASVIR
Ledipasvir in combination with sofosbuvir, or in combination with sofosbuvir and ribavirin, is indicated for the treatment of chronic hepatitis c (chc) genotype 1 infection in adults
SOFOSBUVIR
Sofosbuvir is used in combination therapy to treat chronic hepatitis c virus (hcv) infected patients with hcv genoptype 1,2,3, or 4, and to treat hcv and hiv co-infected patients. The combination therapy includes either ribavirin alone or ribavirin and peg-interferon alfa

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Ledipasvir, Sofosbuvir :

Mechanism of Action

LEDIPASVIR
Ledipasvir is an inhibitor of the hepatitis c virus (hcv) ns5a protein required for viral rna replication and assembly of hcv virions. Although its exact mechanism of action is unknown, it is postulated to prevent hyperphosphorylation of ns5a which is required for viral production. It is effective against genotypes 1a, 1b, 4a, and 5a and with a lesser activity against genotypes 2a and 3a of hcv
SOFOSBUVIR
Sofosbuvir is nucleotide analog inhibitor, which specifically inhibits hcv ns5b polymerase. Sofosbuvir prevents hcv viral replication by binding to the two mg2+ ions present in hcv ns5b polymerase's gdd active site motif

Note

Harvoni "90mg, 400mg" Tablets / Film-coated manufactured by GILEAD SCIENCES INTERNATIONAL LTD. . Its generic name is Ledipasvir, Sofosbuvir. Harvoni is availble in United Arab Emirates. Farmaco UAE drug index information on Harvoni Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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