HUMULIN PROFILE-20 Injection
Insulin - Isophane biphasic (human) (Soluble/Regular 20%, Isophane 80%)
100IU/ml
LILLY FRANCE SA
| Pack size | 10ml Vial |
|---|---|
| Dispensing mode | POM |
| Source | FRANCE |
| Agent | PHARMATRADE |
| Retail Price | 53.00 AED |
Indications
HUMULIN PROFILE-20 Injection is used for:
Indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Insulin - Isophane biphasic (human) (Soluble/Regular 20%, Isophane 80%) :
Mechanism of Action
The primary activity of insulin is the regulation of glucose metabolism. Insulin promotes glucose and amino acid uptake into muscle and adipose tissues, and other tissues except brain and liver. It also has an anabolic role in stimulating glycogen, fatty acid, and protein synthesis. Insulin inhibits gluconeogenesis in the liver.
Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism.
Note
HUMULIN PROFILE-20 100IU/ml Injection manufactured by LILLY FRANCE SA. Its generic name is Insulin - Isophane biphasic (human) (Soluble/Regular 20%, Isophane 80%). HUMULIN PROFILE-20 is availble in United Arab Emirates.
Farmaco UAE drug index information on HUMULIN PROFILE-20 Injection is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.