Hycamtin Infusion
Topotecan
4mg
GLAXOSMITHKLINE MANUFACTURING S.p.A.
| Pack size | 4mg Vial (Powder) x 5 |
|---|---|
| Dispensing mode | POM |
| Source | ITALY |
| Agent | AL ITTIHAD DRUG STORE |
| Retail Price | 4383.50 AED |
Indications
Hycamtin Infusion is used for:
For the treatment of advanced ovarian cancer in patients with disease that has recurred or progressed following therapy with platinum-based regimens. Also used as a second-line therapy for treatment-sensitive small cell lung cancer, as well as in combination with cisplatin for the treatment of stage iv-b, recurrent, or persistent cervical cancer not amenable to curative treatment with surgery and/or radiation therapy
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Topotecan :
Mechanism of Action
Topotecan has the same mechanism of action as irinotecan and is believed to exert its cytotoxic effects during the s-phase of dna synthesis. Topoisomerase i relieves torsional strain in dna by inducing reversible single strand breaks. Topotecan binds to the topoisomerase i-dna complex and prevents religation of these single strand breaks. This ternary complex interferes with the moving replication fork, which leads to the induction of replication arrest and lethal double-stranded breaks in dna. As mammalian cells cannot efficiently repair these double strand breaks, the formation of this ternary complex eventually leads to apoptosis (programmed cell death). Topotecan mimics a dna base pair and binds at the site of dna cleavage by intercalating between the upstream (-1) and downstream (+1) base pairs. Intercalation displaces the downstream dna, thus preventing religation of the cleaved strand. By specifically binding to the enzyme>substrate complex, topotecan acts as an uncompetitive inhibitor
Note
Hycamtin 4mg Infusion manufactured by GLAXOSMITHKLINE MANUFACTURING S.p.A.. Its generic name is Topotecan. Hycamtin is availble in United Arab Emirates.
Farmaco UAE drug index information on Hycamtin Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.