IMDUR Tablets
Isosorbide Mononitrate
60mg
ASTRAZENECA AB
| Pack size | 30's Bottle |
|---|---|
| Dispensing mode | POM |
| Source | SWEDEN |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 28.00 AED |
Available as:
Indications
IMDUR Tablets is used for:
Angina pectoris
Adult Dose
Oral
Angina Pectoris
Prevention of angina pectoris caused by coronary artery disease
Adult: 20 mg 2-3 times daily. Dose may range from 20-120 mg daily.
As LA form: One capsule once daily.
Elderly: Intiate at lower doses.
Child Dose
Safety and efficacy not established
Renal Dose
Administration
Should be taken on an empty stomach (i.e. At least one hour before food or two hours after food).
Contra Indications
Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.
Precautions
Severe renal or severe hepatic impairment, hypothyroidism, malnutrition, or hypothermia. Caution in patients who are already hypotensive. May aggravate angina caused by hypertrophic cardiomyopathy. Tolerance may develop after long-term treatment. Lactation.
Lactation: Unknown whether drug crosses into breast milk; use caution
Pregnancy-Lactation
Pregnancy category: C
Lactation: Unknown whether drug crosses into breast milk; use caution
Interactions
Hypotensive effects may be increased when used with alcohol or vasodilators. Concurrent use with calcium channel blockers may lead to marked orthostatic hypotension.
Potentially Fatal: Significant hypotension may occur when used with phosphodiesterase-5 inhibitors.
Adverse Effects
Side effects of Isosorbide Mononitrate :
Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Restlessness, weakness and vertigo. Dry mouth, chest pain, back pain, oedema, fatigue, abdominal pain, constipation, diarrhoea, dyspepsia and flatulence.
Potentially Fatal: Severe hypotension and cardiac failure.
Mechanism of Action
Isosorbide mononitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).
Note
IMDUR 60mg Tablets manufactured by ASTRAZENECA AB. Its generic name is Isosorbide Mononitrate. IMDUR is availble in United Arab Emirates.
Farmaco UAE drug index information on IMDUR Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.