Irvel Tablets / Film-coated

Irbesartan
150mg
Globalpharma Co. L.L.C.
Pack size 28's (14's Blister x 2)
Dispensing mode POM
Source UAE
AgentGlobalPharma Co. L.L.C.
Retail Price 69.50 AED

Indications

Irvel Tablets / Film-coated is used for: Diabetic nephropathy, Hypertension

Adult Dose

Oral Hypertension Adult: 150 mg once daily, may increase to 300 mg once daily if needed. Patient w/ intravascular volume depletion: Initially, 75 mg once daily. Elderly: >75 yr Initially, 75 mg once daily. Diabetic nephropathy in Type 2 diabetes mellitus Adult: Initially, 75-150 mg once daily, may increase to 300 mg once daily if needed.

Child Dose

Hypertension <6 years: Safety and efficacy not established 6-12 years: 75 mg/day PO initially; not to exceed 150 mg/day >12 years: 150 mg/day PO initially; may be increased to 300 mg/day PO

Renal Dose

Renal impairment: Haemodialysis: Initially, 75 mg once daily. Mild-to-severe renal impairment: Dosage adjustment not necessary unless patient is hypovolemic

Administration

May be taken with or without food.

Contra Indications

Hypersensitivity; pregnancy and lactation.

Precautions

Child <6 yr. Unilateral or bilateral renal artery stenosis; vol or Na depletion; aortic or mitral valve stenosis, hypertrophic cardiomyopathy. Lactation: Potential harm to nursing infant; discontinue drug, or do not nurse

Pregnancy-Lactation

Pregnancy category: 1st trimester, C; 2nd and 3rd trimesters, D

Interactions

May antagonise hypotensive effect and increase risk of nephrotoxicity w/ NSAIDs. May increase serum lithium levels and toxicity. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes. Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).

Adverse Effects

Side effects of Irbesartan : >10% Hyperkalemia (19%) 1-10% Dizziness (10%), Upper respiratory tract infection (URTI) (9%), Orthostatic hypotension (5%), Fatigue (4%), Diarrhea (3%), Dyspepsia (2%)

Mechanism of Action

Irbesartan is an angiotensin II receptor antagonist. It blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by binding to AT1 receptors.

Note

Irvel 150mg Tablets / Film-coated manufactured by Globalpharma Co. L.L.C.. Its generic name is Irbesartan. Irvel is availble in United Arab Emirates. Farmaco UAE drug index information on Irvel Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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