Isoflurane Inhalation
Isoflurane
100%
NATIONAL COMPANY FOR PHARMACEUTICAL INDUSTRY
| Pack size | 100ml Glass Bottle |
|---|---|
| Dispensing mode | POM |
| Source | SYRIA |
| Agent | AL NOOR MEDICAL CO. |
| Retail Price | 167.00 AED |
Indications
Isoflurane Inhalation is used for:
General anaesthesia
Adult Dose
Anesthesia Induction & Maintenance
Use calibrated vaporizer
Induction: 1.5-3% can produce surgical anesthesia in 7-10 minutes
Maintenance: 1-2.5% with nitrous oxide
Additional 0.5-1% may be needed if given with oxygen alone
Child Dose
Safety & efficacy not established
Renal Dose
Administration
Contra Indications
Known or suspected susceptibility to malignant hyperthermia. Porphyria.
Precautions
Perioperative hyperkalaemia; raised intracranial pressure. May impair ability to drive or operate machinery. Pregnancy and lactation. Do not allow carbon dioxide absorbents in anaesthetic apparatus to dry out when delivering isoflurane to minimise the risk of developing elevated carboxyhaemoglobin levels.
Lactation: use caution
Pregnancy-Lactation
Pregnancy
There are no adequate and well-controlled studies in pregnant women; in animal reproduction studies, embryofetal toxicity was noted in pregnant mice exposed to 0.075% (increased post implantation losses) and 0.3% isoflurane (increased post implantation losses and decreased live- birth index) during organogenesis
Lactation
Use caution
Interactions
Enhances effects of neuromuscular blockers. May sensitise the myocardium to adrenaline and other sympathomimetics. Enhances hypotensive effects of ACE inhibitors, TCAs, MAOIs, antihypertensives, antipsychotics or beta-blockers. May have synergistic effects with CNS depressants.
Adverse Effects
Side effects of Isoflurane :
1-10%
Nausea, Vomiting, Shivering
<1%
Dose-dependent hypotension, Arrhythmias, Malignant hyperthermia (rare), Elevations in white blood count, May decrease creatinine and increase BUN, Ileus, severe (fatal), Hepatic dysfunction (postoperative period) (rare), Respiratory depression may occur (rare)
Mechanism of Action
Isoflurane, a volatile halogenated anaesthetic, causes a reversible loss of consciousness and pain sensations, suppression of voluntary motor activity, modification of autonomic reflexes, and depression of the respiratory and the CV system.
Note
Isoflurane 100% Inhalation manufactured by NATIONAL COMPANY FOR PHARMACEUTICAL INDUSTRY. Its generic name is Isoflurane. Isoflurane is availble in United Arab Emirates.
Farmaco UAE drug index information on Isoflurane Inhalation is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.