Isoket Retard Tablets

Isosorbide Dinitrate
40mg
SCHWARZ PHARMA GmbH
Pack size 50's (10's Blister x 5)
Dispensing mode POM
Source GERMANY
AgentModern Pharmaceutical Co.
Retail Price 50.50 AED

Indications

Isoket Retard Tablets is used for: Angina, Percutaneous transluminal coronary angioplasty

Adult Dose

Angina Pectoris Immediate release: 5-20 mg PO q8-12hr initially; maintenance: 10-40 mg PO q8-12hr

Child Dose

Renal Dose

Administration

Should be taken on an empty stomach. Take on an empty stomach ½ hr before meals.

Contra Indications

Severe hypotension or anaemia, hypovolaemia, heart failure due to obstruction, or raised intracranial pressure due to head trauma or cerebral haemorrhage.

Precautions

Raised intracranial pressure, hypotension, hypovolaemia. Mitral valve prolapse, arterial hypoxaemia, glaucoma, elderly, hypothyroidism, malnutrition, pregnancy, lactation Lactation: Unknown whether drug is distributed into breast milk

Pregnancy-Lactation

Pregnancy category: C Lactation: Unknown whether drug is distributed into breast milk

Interactions

Increased hypotensive effects with alcohol or vasodilators. Marked orthostatic hypotension may occur when used with calcium channel blockers. Vasodilatory effect may be reduced with dihydroergotamine. Ergotamine effects may be enhanced. Reduced effectiveness of sublingual form with disopyramide. Potentially Fatal: Significant hypotension may occur with phosphodiesterase-5 inhibitors.

Adverse Effects

Side effects of Isosorbide Dinitrate : Cardiovascular: Rebound hypertension (uncommon), syncope, unstable angina flushing, hypotension/orthostatic hypotension, lightheadedness, palpitations, tachyarrhythmia Central nervous system (CNS): Dizziness, headache, restlessness, weakness Gastrointestinal (GI): Nausea Hematologic: Methemoglobinemia (infrequent) Potentially Fatal: Severe hypotension, circulatory collapse.

Mechanism of Action

Isosorbide dinitrate relaxes vascular smooth muscles by stimulating cyclic-GMP. It decreases left ventricular pressure (preload) and arterial resistance (afterload).

Note

Isoket Retard 40mg Tablets manufactured by SCHWARZ PHARMA GmbH. Its generic name is Isosorbide Dinitrate. Isoket Retard is availble in United Arab Emirates. Farmaco UAE drug index information on Isoket Retard Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

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