JIVI Infusion
Damoctocog alfa pegol
1000 IU / Vial
BAYER AG
| Pack size | 1 Glass Vial of Powder (10 ml) + 1 Pre-Filled Syringe of Solvent + 1 Separate Plunger Rod + 1 Vial Adapter with Filter + 1 Venipuncture Set |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | ALPHAMED DRUG STORE |
| Retail Price | 4258.50 AED |
Available as:
Indications
JIVI Infusion is used for:
Indicated for use in previously treated adults and adolescents (12 years of age and above) with hemophilia A (congenital Factor VIII deficiency) for:
On-demand treatment and control of bleeding episodes [FDA label], perioperative management of bleeding [FDA label], and routine prophylaxis to reduce the frequency of bleeding episodes [FDA label].
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Damoctocog alfa pegol :
Mechanism of Action
This drug is a site-specifically PEGylated recombinant antihemophilic factor, which temporarily replaces the missing coagulation Factor VIII. The site-specific PEGylation in the A3 domain reduces binding to the physiological Factor VIII clearance receptors resulting in a longer half-life and increased AUC (area under the curve) [FDA label].
The active protein, prior to conjugation is a recombinant B-domain deleted human coagulation Factor VIII (BDD-rFVIII) produced by recombinant DNA technology in Baby Hamster Kidney (BHK) cells [FDA label].
Damoctagol alfa pegol is manufactured by site-specific conjugation of the BDD-rFVIII variant K1804C at the cysteine amino acid position 1804 (within the A3 domain) with a single maleimide-derivatized, 60 kilodalton (kDa) branched PEG (two 30 kDa PEG) moiety. The A3 domain was identified and selected for conjugation to provide both a continual coagulation activity and high PEGylation efficiency [FDA label].
Note
JIVI 1000 IU / Vial Infusion manufactured by BAYER AG. Its generic name is Damoctocog alfa pegol. JIVI is availble in United Arab Emirates.
Farmaco UAE drug index information on JIVI Infusion is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.