LESCOL XL Tablets / Film-coated
Fluvastatin
80mg
Novartis Pharma AG
| Pack size | 28's (14's Blister x 2) |
|---|---|
| Dispensing mode | POM |
| Source | SWITZERLAND |
| Agent | CITY MEDICAL STORE |
| Retail Price | 144.00 AED |
Indications
LESCOL XL Tablets / Film-coated is used for:
Hyperlipidaemias, Hypercholesterolemia
Adult Dose
Oral
Hypercholesterolemia & Mixed Dyslipidemia
Adult: Initially, 20-40 mg once daily in the evening, may increase at intervals of 4 wk to max 80 mg/day in 12hrly divided dose.
Hepatic Impairment
Contraindicated in active liver disease or unexplained transaminase elevations
Child Dose
Oral
Hyperlipidaemias
Child: Heterozygous familial hypercholesterolaemia: 10-16 yr 20 mg once daily. If necessary, may increase dose at 6-wkly intervals to 40 mg bid or 80 mg once daily as modified-release.
Renal Dose
Renal Impairment
CrCl <30 mL/min: Adjust dose amount; not to exceed 40 mg/day
Administration
May be taken with or without food.
Contra Indications
Acute liver disease; unexplained persistently raised serum aminotransferase concentrations; porphyria; pregnancy; lactation.
Precautions
History of liver disease; high alcohol intake. Manage hypothyroidism adequately before starting treatment. Report unexplained muscle pain. Monitor LFTs. Discontinue in case of marked or persistent increase in serum aminotransferase or creatine phosphokinase. Severe renal impairment.
Lactation: enters breast milk; contraindicated
Pregnancy-Lactation
Pregnancy Category: X
Lactation: enters breast milk; contraindicated
Interactions
Bleeding and increased prothrombin time w/ coumarin anticoagulants. May increase the risk of myopathy and rhabdomyolysis w/ HIV protease inhibitors, colchicine, bezafibrate, ciprofibrate or niacin (nicotinic acid), ciclosporin and fluconazole. Reduced bioavailability w/ concomitant rifampicin.
Adverse Effects
Side effects of Fluvastatin :
1-10%
Headache (9%), Dyspepsia (8%), Abdominal pain (5%), Diarrhea (5%), Myalgia (5%), Fatigue (3%), Insomnia (3%), Nausea (3%), Sinusitis (3%), Bronchitis (2%), UTI (2%), Transaminases increased (1.1%)
<1%
Rash, Back pain, Arthralgia, Myopathy, Rhabdomyolysis, Rupture of tendon, CPK increased, Pharyngitis, Rhinitis, Cough, Constipation, Pancreatitis, Dizziness
Mechanism of Action
Fluvastatin acts by competitively inhibiting HMG-CoA reductase, the enzyme for cholesterol synthesis. It reduces total cholesterol, triglycerides, LDL and VLDL concentrations in plasma. It also increases HDL concentrations.
Note
LESCOL XL 80mg Tablets / Film-coated manufactured by Novartis Pharma AG. Its generic name is Fluvastatin. LESCOL XL is availble in United Arab Emirates.
Farmaco UAE drug index information on LESCOL XL Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.