Leukeran Tablets / Film-coated
Chlorambucil
2mg
EXCELLA GmbH
| Pack size | 25's Glass Bottle |
|---|---|
| Dispensing mode | POM |
| Source | GERMANY |
| Agent | AL BAKER TRADING EST. |
| Retail Price | 343.00 AED |
Indications
Leukeran Tablets / Film-coated is used for:
Lymphocytic leukemia, non-Hodgkin lymphoma, Waldenstrm macroglobulinemia, polycythemia vera, trophoblastic neoplasms, ovarian carcinoma, nephrotic syndrome, Hodgkin's disease
Adult Dose
Chronic Lymphatic (Lymphocytic) Leukemia
0.1 mg/kg/day for 3-6 weeks or
0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or
0.4 mg/kg (increased by 0.1 mg/kg/dose until response observed) monthly or
0.03-0.1 mg/kg/day continuously
Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease
Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes
Hodgkin's Lymphoma
0.2 mg/kg/day for 3-6 weeks or
0.4 mg/kg (increased by 0.1 mg/kg/dose until response/toxicity observed) biweekly or
0.4 mg/kg (increased by 0.1 mg/kg/dose until response or toxicity observed) monthly or
0.03-0.1 mg/kg/day continuously
Reduce initial dose if administered within 4 weeks after a full course of radiation/myelosuppressive therapy or patients with bone marrow disease
Not to exceed 0.1 mg/kg/day if bone marrow infiltrated with lymphocytes
Hepatic Impairment
Primarily metabolized in liver; dose reduction may be required
Child Dose
Renal Dose
Renal Impairment
<1% (including metabolites) excreted in urine; no dose adjustment required
Administration
Should be taken on an empty stomach. Take on an empty stomach. Ensure adequate hydration. Swallow whole, do not chew/crush.
Contra Indications
Hypersensitivity. Pregnancy and lactation. Porphyria.
Precautions
Renal or hepatic dysfunction. Perform blood counts regularly. Seizure disorder, bone marrow suppression. Patient who has received radiation therapy, myelosuppressive drugs or has a depressed baseline leukocyte/platelet count within the previous 4 wk. Increased incidence of acute leukaemias and other secondary malignancies.
Lactation: not known if excreted in breast milk; do not nurse
Pregnancy-Lactation
Pregnancy Category: D
Lactation: not known if excreted in breast milk; do not nurse
Interactions
Impairs immune response to vaccines, possible infection after admin of live vaccines.
Adverse Effects
Side effects of Chlorambucil :
>10%
Neutropenia (25-33%), Anemia, Leukopenia, Thrombocytopenia
Frequency Not Defined
Seizures, Hallucinations, Peripheral neuropathy, Nausea, Vomiting, Pulmonary fibrosis, GI effects, Leukemia, Myelosuppression, Hyperuricemia, Infertility, Hepatotoxicity & jaundice, Type I hypersensitivity, Rash, Stevens-Johnson syndrome (rare), Toxic epidermal necrosis (rare), Urticaria, Erythema multiforme (rare), Secondary malignancies
Potentially Fatal: Severe bone marrow suppression, carcinogenic and human infertility.
Mechanism of Action
Chlorambucil interferes with DNA replication and RNA transcription by alkylation and cross-linking cellular DNA strands, thus leading to disruption of the nucleic acid function.
Note
Leukeran 2mg Tablets / Film-coated manufactured by EXCELLA GmbH. Its generic name is Chlorambucil. Leukeran is availble in United Arab Emirates.
Farmaco UAE drug index information on Leukeran Tablets / Film-coated is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.