Lipostat Tablets

Pravastatin sodium
20mg
BRISTOL MYERS SQUIBB MANUFACTURING COMPANY
Pack size 30's HDPE Bottle
Dispensing mode POM
Source USA
AgentModern Pharmaceutical Co.
Retail Price 114.50 AED

Indications

Lipostat Tablets is used for: For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease.

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Pravastatin sodium :

Mechanism of Action

Pravastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Unlike its parent compound, mevastatin, and statins such as lovastatin and simvastatin, pravastatin does not need to be activated in vivo. Its hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with a much greater affinity than its natural substrate. The bicyclic portion of pravastatin binds to the coenzyme A portion of the active site. Pravastatin sodium produces its lipid-lowering effect in two ways. First, as a consequence of its reversible inhibition of HMG-CoA reductase activity, it effects modest reductions in intracellular pools of cholesterol. This results in an increase in the number of LDL-receptors on cell surfaces and enhanced receptor-mediated catabolism and clearance of circulating LDL. Second, pravastatin inhibits LDL production by inhibiting hepatic synthesis of VLDL, the LDL precursor.

Note

Lipostat 20mg Tablets manufactured by BRISTOL MYERS SQUIBB MANUFACTURING COMPANY. Its generic name is Pravastatin sodium. Lipostat is availble in United Arab Emirates. Farmaco UAE drug index information on Lipostat Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Pravastatin sodium :