Lipostat Tablets
Pravastatin sodium
20mg
BRISTOL MYERS SQUIBB MANUFACTURING COMPANY
| Pack size | 30's HDPE Bottle |
|---|---|
| Dispensing mode | POM |
| Source | USA |
| Agent | Modern Pharmaceutical Co. |
| Retail Price | 114.50 AED |
Available as:
Indications
Lipostat Tablets is used for:
For the treatment of hypercholesterolemia and to reduce the risk of cardiovascular disease.
Adult Dose
Child Dose
Renal Dose
Administration
Contra Indications
Precautions
Pregnancy-Lactation
Interactions
Adverse Effects
Side effects of Pravastatin sodium :
Mechanism of Action
Pravastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. Unlike its parent compound, mevastatin, and statins such as lovastatin and simvastatin, pravastatin does not need to be activated in vivo. Its hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind with a much greater affinity than its natural substrate. The bicyclic portion of pravastatin binds to the coenzyme A portion of the active site. Pravastatin sodium produces its lipid-lowering effect in two ways. First, as a consequence of its reversible inhibition of HMG-CoA reductase activity, it effects modest reductions in intracellular pools of cholesterol. This results in an increase in the number of LDL-receptors on cell surfaces and enhanced receptor-mediated catabolism and clearance of circulating LDL. Second, pravastatin inhibits LDL production by inhibiting hepatic synthesis of VLDL, the LDL precursor.
Note
Lipostat 20mg Tablets manufactured by BRISTOL MYERS SQUIBB MANUFACTURING COMPANY. Its generic name is Pravastatin sodium. Lipostat is availble in United Arab Emirates.
Farmaco UAE drug index information on Lipostat Tablets is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.