Locasalen Ointment

Flumethasone, Salycilic acid
"0.2mg, 30mg/g"
Novartis Pharma AG
Pack size 15g Tube
Dispensing mode POM
Source SWITZERLAND
AgentCITY MEDICAL STORE
Retail Price 28.50 AED

Indications

Locasalen Ointment is used for: FLUMETHASONE
For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditions
SALICYLIC ACID
Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts

Adult Dose

Child Dose

Renal Dose

Administration

Contra Indications

Precautions

Pregnancy-Lactation

Interactions

Adverse Effects

Side effects of Flumethasone, Salycilic acid :

Mechanism of Action

FLUMETHASONE
Flumethasone is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase a2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin
SALICYLIC ACID
Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (cox-1 and cox-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (udpg) competitively with nicotinamide adenosine dinucleotide (nad) and noncompetitively with udpg. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (udpga) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis

Note

Locasalen "0.2mg, 30mg/g" Ointment manufactured by Novartis Pharma AG. Its generic name is Flumethasone, Salycilic acid. Locasalen is availble in United Arab Emirates. Farmaco UAE drug index information on Locasalen Ointment is not intended for diagnosis, medical advice or treatment; neither intended to be a substitute for the exercise of professional judgment.

Some other brands of Flumethasone, Salycilic acid :